Repository logo
 
Publication

Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock

2014Journal article Open access
Simple item page
dc.contributor.authorResende, Tatiana P.
dc.contributor.authorAndrade, Raquel P.
dc.contributor.authorPalmeirim, Isabel
dc.date.accessioned2018-12-07T14:58:28Z
dc.date.available2018-12-07T14:58:28Z
dc.date.issued2014
dc.description.abstractAll vertebrate species present a segmented body, easily observed in the vertebrate column and its associated components, which provides a high degree of motility to the adult body and efficient protection of the internal organs. The sequential formation of the segmented precursors of the vertebral column during embryonic development, the somites, is governed by an oscillating genetic network, the somitogenesis molecular clock. Herein, we provide an overview of the molecular clock operating during somite formation and its underlying molecular regulatory mechanisms. Human congenital vertebral malformations have been associated with perturbations in these oscillatory mechanisms. Thus, a better comprehension of the molecular mechanisms regulating somite formation is required in order to fully understand the origin of human skeletal malformations.
dc.description.sponsorshipFundacao paraa Ciencia e a Tecnologia, Portugal [SFRH/BD/27796/2006, SFRH/BPD/80588/2011]; Programa Operacional Regional do Norte (ON.2) [NORTE-07-0124-FEDER-000017]; Centro de Biomedicina Molecular e Estrutural, LA; Fundacao para a Ciencia e a Tecnologia (National and FEDER COMPETE Program funds) [PTDC/SAU-BID/121459/2010, PTDC/SAU-OBD/099758/2008]; [PEst-OE/EQB/LA0023/2011]
dc.identifier.doi10.1155/2014/718683
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.urihttp://hdl.handle.net/10400.1/12043
dc.language.isoeng
dc.peerreviewedyes
dc.publisherHindawi Ltd
dc.relationREGENERATIVE POTENTIAL OF CARDIAC PROGENITORS: FROM THE EMBRYO TO ADULTHOOD
dc.relationMolecular parallelisms in vertebrate somitogenesis and limb development
dc.subjectPresomitic mesoderm cells
dc.subjectSomite boundary formation
dc.subjectNegative feedback loop
dc.subjectLunatic-fringe
dc.subjectChick-embryo
dc.subjectAvian embryos
dc.subjectPrimitive streak
dc.subjectGene-expression
dc.subjectMouse embryos
dc.subjectOscillatory expression
dc.titleTiming embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleREGENERATIVE POTENTIAL OF CARDIAC PROGENITORS: FROM THE EMBRYO TO ADULTHOOD
oaire.awardTitleMolecular parallelisms in vertebrate somitogenesis and limb development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F27796%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F80588%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FSAU-BID%2F121459%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-OBD%2F099758%2F2008/PT
oaire.citation.startPage718683
oaire.citation.titleBioMed Research International
oaire.fundingStreamSFRH
oaire.fundingStreamCOMPETE
oaire.fundingStream3599-PPCDT
person.familyNameAndrade
person.familyNamePalmeirim
person.givenNameRaquel
person.givenNameIsabel
person.identifier.ciencia-id2312-360B-227A
person.identifier.ciencia-id141A-4DE2-6FF3
person.identifier.orcid0000-0002-0397-5917
person.identifier.orcid0000-0003-2282-7829
person.identifier.scopus-author-id7103114918
person.identifier.scopus-author-id6603305227
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationf2d3fc39-a8f6-4d83-9e60-2e2fdfbc2b4a
relation.isAuthorOfPublication19d625d8-5aae-462b-b83a-ad10a155897f
relation.isAuthorOfPublication.latestForDiscoveryf2d3fc39-a8f6-4d83-9e60-2e2fdfbc2b4a
relation.isProjectOfPublication58b8974e-add3-4da2-90b9-8bc2d516636d
relation.isProjectOfPublication62f9b4f8-f5bf-4acd-8ffd-58144cd8462c
relation.isProjectOfPublication37beaf0f-8836-4e26-a95e-54ed7b17d6ed
relation.isProjectOfPublication5d05af5f-2d78-4436-8d7e-4360d6b3c246
relation.isProjectOfPublication.latestForDiscovery5d05af5f-2d78-4436-8d7e-4360d6b3c246

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
12043.pdf
Size:
1.34 MB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)