Repository logo
 
Publication

S-nitrosation and neuronal plasticity

2015-03Journal article Open access
Simple item page
dc.contributor.authorSantos, Ana Isabel
dc.contributor.authorMartinez-Ruiz, A.
dc.contributor.authorAraújo, Inês
dc.date.accessioned2018-12-07T14:53:41Z
dc.date.available2018-12-07T14:53:41Z
dc.date.issued2015-03
dc.description.abstractNitric oxide (NO) has long been recognized as a multifaceted participant in brain physiology. Despite the knowledge that was gathered over many years regarding the contribution of NO to neuronal plasticity, for example the ability of the brain to change in response to new stimuli, only in recent years have we begun to understand how NO acts on the molecular and cellular level to orchestrate such important phenomena as synaptic plasticity (modification of the strength of existing synapses) or the formation of new synapses (synaptogenesis) and new neurons (neurogenesis). Post-translational modification of proteins by NO derivatives or reactive nitrogen species is a non-classical mechanism for signalling by NO. S-nitrosation is a reversible post-translational modification of thiol groups (mainly on cysteines) that may result in a change of function of the modified protein. S-nitrosation of key target proteins has emerged as a main regulatory mechanism by which NO can influence several levels of brain plasticity, which are reviewed in this work. Understanding how S-nitrosation contributes to neural plasticity can help us to better understand the physiology of these processes, and to better address pathological changes in plasticity that are involved in the pathophysiology of several neurological diseases. Linked ArticlesThis article is part of a themed section on Pharmacology of the Gasotransmitters. To view the other articles in this section visit
dc.description.sponsorshipFEDER funds via Programa Operacional Factores de Competitividade (COMPETE); COST action [BM1005]; Foundation for Science and Technology (FCT, Portugal) [PTDC/SAU-OSD/0473/2012, PEst-C/SAU/LA0001/2013-2014, PEst-OE/EQB/LA0023/2013-2014]; Spanish-Portuguese Integrated Action grant [PRI-AIBPT-2011-1015/E-10/12]; FCT [SFRH/BD/77903/2011]; I3SNS programme (ISCIII, Spanish Government)
dc.description.sponsorshipPEst-OE/EQB/LA0023/2013-2014; PRI-AIBPT-2011-1015/E-10/12
dc.identifier.doi10.1111/bph.12827
dc.identifier.issn0007-1188
dc.identifier.issn1476-5381
dc.identifier.urihttp://hdl.handle.net/10400.1/11636
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley-Blackwell
dc.relationEnhancement of endogenous neurogenesis by nitric oxide: identification of S-nitrosylation targets
dc.subjectNitric-Oxide Synthase
dc.subjectLong-Term Potentiation
dc.subjectProtein-Tyrosine Nitration
dc.subjectGrowth-Factor Receptor
dc.subjectSynaptic Plasticity
dc.subjectAdult Neurogenesis
dc.subjectDentate Gyrus
dc.subjectConcise Guide
dc.subjectStem-Cells
dc.subjectNeurodegenerative Diseases
dc.titleS-nitrosation and neuronal plasticity
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEnhancement of endogenous neurogenesis by nitric oxide: identification of S-nitrosylation targets
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FNEU-OSD%2F0473%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F77903%2F2011/PT
oaire.citation.endPage1478
oaire.citation.issue6
oaire.citation.startPage1468
oaire.citation.titleBritish Journal of Pharmacology
oaire.citation.volume172
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
person.familyNameSantos
person.familyNamePombinho de Araújo
person.givenNameAna Isabel
person.givenNameInês Maria
person.identifierF-4703-2012
person.identifier.ciencia-idA31D-E831-28E8
person.identifier.ciencia-idD11F-D4CA-2947
person.identifier.orcid0000-0003-2070-0285
person.identifier.orcid0000-0002-2438-0111
person.identifier.scopus-author-id55019179900
person.identifier.scopus-author-id56271084100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication71b27a1a-a03a-4d9b-80e6-60d22840f569
relation.isAuthorOfPublication1d0c21f4-0f4b-4589-8412-fe1079419774
relation.isAuthorOfPublication.latestForDiscovery1d0c21f4-0f4b-4589-8412-fe1079419774
relation.isProjectOfPublication204ca908-a8e6-460e-b936-697f819650d0
relation.isProjectOfPublication4f1d7915-299b-4cd1-97c9-d4acf0ca6dcf
relation.isProjectOfPublication.latestForDiscovery204ca908-a8e6-460e-b936-697f819650d0

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
S-nitrosation and neuronal plasticity.pdf
Size:
483.2 KB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)