Percorrer por autor "Baby, André Rolim"
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- Anticancer activity of rutin and its combination with ionic liquids on renal cellsPublication . Caparica, Rita; Júlio, Ana; Araújo, Maria Eduarda Machado; Baby, André Rolim; Fonte, Pedro; Costa, João Guilherme; Santos de Almeida, TâniaThe renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel and more effective therapies, while minimizing toxicity, continues to be fundamental in curtailing RCC. Rutin, a bioflavonoid widely found in nature, has shown promising anticancer properties, but with limited applicability due to its poor water solubility and pharmacokinetics. Thus, the potential anticancer effects of rutin toward a human renal cancer cell line (786-O), while considering its safety in Vero kidney cells, was assessed, as well as the applicability of ionic liquids (ILs) to improve drug delivery. Rutin (up to 50 µM) did not show relevant cytotoxic effects in Vero cells. However, in 786-O cells, a significant decrease in cell viability was already observed at 50 µM. Moreover, exposure to rutin caused a significant increase in the sub-G1 population of 786-O cells, reinforcing the possible anticancer activity of this biomolecule. Two choline-amino acid ILs, at non-toxic concentrations, enhanced rutin's solubility/loading while allowing the maintenance of rutin's anticancer effects. Globally, our findings suggest that rutin may have a beneficial impact against RCC and that its combination with ILs ensures that this poorly soluble drug is successfully incorporated into ILs-nanoparticles hybrid systems, allowing controlled drug delivery.
- Pluronic® triblock copolymer-based nanoformulations for cancer therapy: A 10-year overviewPublication . de Castro, Karine Cappuccio; Coco, Julia Cedran; dos Santos, Érica Mendes; Ataide, Janaína Artem; Martinez, Renata Miliani; do Nascimento, Mônica Helena Monteiro; Prata, João; Fonte, Pedro; Severino, Patrícia; Mazzola, Priscila Gava; Baby, André Rolim; Souto, Eliana Barbosa; de Araujo, Daniele Ribeiro; Lopes, André MoreniThis paper provides a review of the literature on the use of Pluronic (R) triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic (R) triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to inno-vative examples for improving tumor cytotoxicity while reducing side effects.