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Publication
Pluronic® triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview
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Advisor(s)
Abstract(s)
This paper provides a review of the literature on the use of Pluronic (R) triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic (R) triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to inno-vative examples for improving tumor cytotoxicity while reducing side effects.
Description
Keywords
Pluronic? Amphiphilic copolymers Self-assembly Drug delivery systems (DDS) Nanostructures (NSs) Cancer therapy
Citation
Publisher
Elsevier