Browsing by Author "Fernandes, Ricardo"
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- Human forager response to abrupt climate change at 8.2 ka on the Atlantic coast of EuropePublication . García-Escárzaga, Asier; Gutiérrez-Zugasti, Igor; Marín-Arroyo, Ana B.; Fernandes, Ricardo; Núñez de la Fuente, Sara; Cuenca-Solana, David; Iriarte, Eneko; Simões, Carlos; Martín-Chivelet, Javier; González-Morales, Manuel R.; Roberts, PatrickThe cooling and drying associated with the so-called ‘8.2 ka event’ have long been hypothesized as having sweeping implications for human societies in the Early Holocene, including some of the last Mesolithic hunter-gatherers in Atlantic Europe. Nevertheless, detailed ‘on-site’ records with which the impacts of broader climate changes on human-relevant environments can be explored have been lacking. Here, we reconstruct sea surface temperatures (SST) from δ18O values measured on subfossil topshells Phorcus lineatus exploited by the Mesolithic human groups that lived at El Mazo cave (N Spain) between 9 and 7.4 ka. Bayesian modelling of 65 radiocarbon dates, in combination with this δ18O data, provide a high-resolution seasonal record of SST, revealing that colder SST during the 8.2 ka event led to changes in the availability of different shellfish species. Intensification in the exploitation of molluscs by humans indicates demographic growth in these Atlantic coastal settings which acted as refugia during this cold event.
- Real-world healthcare resource use associated with recurrent or metastatic head and neck cancer patients care in Portugal—TRACE StudyPublication . Teixeira, Maria Margarida; Dias, João; André, Teresa; Joaquim, Ana; Fernandes, Ricardo; Magalhães, Joana; Marreiros, Laura; Pinto, Leonor; Ribeiro, Leonor; Nogueira, Mafalda; Morais, CatarinaRecurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is a challenging disease, requiring personalized management by a multidisciplinary team. The aim of this retrospective multicentric study was to characterize real-world healthcare resource use and patient care for R/M HNSCC in Portugal during the first year after diagnosis. A total of 377 patients ineligible for curative treatment were included, mostly male (92.8%), aged 50-69 years (74.5%), with heavy alcohol (72.7%) or smoking habits (89.3%). Oropharynx (33.2%) and oral cavity (28.7%) were primary tumor locations, with lung metastases being the most common (61.4%). Eligible patients for systemic treatment with palliative intent (80.6%) received up to four treatment lines, with varied regimens. Platinum-based combination chemotherapy dominated first-line treatment (>70%), while single-agent chemotherapy and anti-PD1 immunotherapy were prevalent in later lines. Treatment approaches were uniform across disease stages and primary tumor locations but varied geographically. Treated patients received more multidisciplinary support than those who were ineligible. This study provides the first Portuguese real-world description of R/M HNSCC patient characteristics, treatment patterns, and supportive care during the year after diagnosis, highlighting population heterogeneity and aiming to improve patient management.
- The Caribbean and Mesoamerica Biogeochemical Isotope Overview (CAMBIO)Publication . Ebert, Claire E.; Hixon, Sean W.; Buckley, Gina M.; George, Richard J.; Pacheco-Fores, Sofía I.; Palomo, Juan Manuel; Sharpe, Ashley E.; Solís-Torres, Óscar R.; Davis, J. Britt; Fernandes, Ricardo; Kennett, Douglas J.The Caribbean & Mesoamerica Biogeochemical Isotope Overview (CAMBIO) is an archaeological data community designed to integrate published biogeochemical data from the Caribbean, Mesoamerica, and southern Central America to address questions about dynamic interactions among humans, animals, and the environment in the region over the past 10,000 years. Here we present the CAMBIO human dataset, which consists of more than 16,000 isotopic measurements from human skeletal tissue samples (delta 13C, delta 15N, delta 34S, delta 18O, 87Sr/86Sr, 206/204Pb, 207/204Pb, 208/204Pb, 207/206Pb) from 290 archaeological sites dating between 7000 BC to modern times. The open-access dataset also includes detailed chronological, contextual, and laboratory/sample preparation information for each measurement. The collated data are deposited on the open-access CAMBIO data community via the Pandora Initiative data platform (https://pandoradata.earth/organization/cambio).