Percorrer por autor "Lopes, Ana"
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- Effectiveness and long-term retention of anti-tumour necrosis factor treatment in juvenile and adult patients with juvenile idiopathic arthritis: data from Reuma.ptPublication . Mourao, Ana F.; Santos, Maria J.; Melo Gomes, Jose A.; Martins, Fernando M.; Mendonca, Silvia C.; Ramos, Filipa Oliveira; Fernandes, Susana; Salgado, Manuel; Guedes, Margarida; Carvalho, Sonia; Costa, Jose A.; Brito, Iva; Duarte, Catia; Furtado, Carolina; Lopes, Ana; Rodrigues, Ana; Sequeira, Graca; Branco, Jaime C.; Fonseca, Joao E.; Canhao, HelenaMethods. We prospectively collected patient and disease characteristics from patients with JIA who started biological therapy. Adverse events were collected during the follow-up period. Predictors of response at 1 year and drug retention rates were assessed at 4 years of treatment for the first biologic agent.Results. A total of 812 JIA patients [65% females, mean age at JIA onset 6.9 years (s.d. 4.7)], 227 received biologic therapy; 205 patients (90.3%) were treated with an anti-TNF as the first biologic. All the parameters used to evaluate disease activity, namely number of active joints, ESR and Childhood HAQ/HAQ, decreased significantly at 6 months and 1 year of treatment. The mean reduction in Juvenile Disease Activity Score 10 (JADAS10) after 1 year of treatment was 10.4 (s.d. 7.4). According to the definition of improvement using the JADAS10 score, 83.3% respond to biologic therapy after 1 year. Fourteen patients discontinued biologic therapies due to adverse events. Retention rates were 92.9% at 1 year, 85.5% at 2 years, 78.4% at 3 years and 68.1% at 4 years of treatment. Among all JIA subtypes, only concomitant therapy with corticosteroids was found to be univariately associated with withdrawal of biologic treatment (P = 0.016).Conclusion. Biologic therapies seem effective and safe in patients with JIA. In addition, the retention rates for the first biologic agent are high throughout 4 years.
- Exploring offshore sediment evidence of the 1755 CE Tsunami (Faro, Portugal): implications for the study of outer shelf Tsunami depositsPublication . Kümmerer, Vincent; Drago, Teresa; C. Veiga-Pires, C.; Silva, Pedro F.; Magalhães, Vitor; Mena, Anxo; Lopes, Ana; Rodrigues, Ana Isabel; Schmidt, Sabine; Terrinha, Pedro; Baptista, Maria AnaOuter shelf sedimentary records are promising for determining the recurrence intervals of tsunamis. However, compared to onshore deposits, offshore deposits are more difficult to access, and so far, studies of outer shelf tsunami deposits are scarce. Here, an example of studying these deposits is presented to infer implications for tsunami-related signatures in similar environments and potentially contribute to pre-historic tsunami event detections. A multidisciplinary approach was performed to detect the sedimentary imprints left by the 1755 CE tsunami in two cores, located in the southern Portuguese continental shelf at water depths of 58 and 91 m. Age models based on 14C and 210Pbxs allowed a probable correspondence with the 1755 CE tsunami event. A multi-proxy approach, including sand composition, grain-size, inorganic geochemistry, magnetic susceptibility, and microtextural features on quartz grain surfaces, yielded evidence for a tsunami depositional signature, although only a subtle terrestrial signal is present. A low contribution of terrestrial material to outer shelf tsunami deposits calls for methodologies that reveal sedimentary structures linked to tsunami event hydrodynamics. Finally, a change in general sedimentation after the tsunami event might have influenced the signature of the 1755 CE tsunami in the outer shelf environment.
- Minute city concept for healthy tourism during the COVID-19 pandemic crisis. who for? The city of Lagos, PortugalPublication . Pires Rosa, Manuela; Lopes, Ana; Aghaeizadeh, Esmaeil; Gomes, André; Andraz, JorgeUrban spatial organization provided an important contribution for healthy tourism in the first COVID-19 pandemic period. The 15-Minute City concept promotes walking which is essential for the development of outdoor activities for a healthier tourism. The tourist city of Lagos (Portugal) is a pilot city of the Interreg Med SuSTowns Project which aims to promote sustainable and resilient territories. This study presents an analysis of the pedestrian accessibility through a specific geographical indicator: the percentage of short-term rentals existing in the surrounding tourist attractions. Ideal standard distances, studied internationally, were considered to assess this close proximity. Different walking speeds were considered to address human diversity and their implications on the 15-Minute City concept. The functionalities of the geographic information systems, in particular the assessment of distances over the pedestrian network were used. The results indicate that in the city of Lagos there is a trend towards an effective 15-Minute City for healthy tourists, promoting walking which could enhance tourism attraction. For tourists with reduced mobility, the use of accessible public transportation is required and needs to be integrated in the 15-Minute City concept.
- Multidisciplinary characterization of Quaternary mass movement deposits in the Portimao Bank (Gulf of Cadiz, SW Iberia)Publication . Silva, P. F.; Roque, C.; Drago, T.; Belen, A.; Henry, B.; Gemma, E.; Lopes, Ana; Lopez-Gonzalez, N.; Casas, D.; Naughton, F.; Naughton, F.We present a multidisciplinary study of the seismic stratigraphy, sedimentology, geochemistry and magnetism to characterize the Quaternary mass movement deposits (MMD) and the associated deformation in the Portimao Bank (Gulf of Cadiz, offshore SW Iberia). Two scales of approach have been applied. At large-scale (m to km) approach, were recognized and characterized a series of important and subsequent slide scars (tens of meters high) and MMD (the larger one with 10 km length) related to landslides, more prominent at Portimao Bank's southern flank. At small-scale (cm) approach, we point out on a piston core collected within a scar affected by MMD, a replication of the sedimentary column as evidenced by geochronological results and corroborated by sedimentology, geochemistry and magnetic data. Magnetic fabric data enabled the identification and characterization of the internal structure and deformation of MMD along the sedimentary column. For last, geochronology and the morphology of Portimao seamount are discussed in order to constraint the factors controlling MMD triggering. The multidisciplinary approach is useful in a better characterization of the MMD at different scales and improved the understanding of its dynamics.
- Multiproxy characterization of high energy layers in the nner continental shelf of Quarteira (Southern Portugal) - Preliminary resultsPublication . Santos, Jacqueline; Drago, Teresa; Moura, Delminda; Magalhães, Vitor; Roque, Cristina; Silva, Pedro F.; Rodrigues, Ana Isabel; Terrinha, Pedro; Anxo, Mena; Francés, Guillermo; Lopes, Ana; Alberto, Ana; Baptista, Maria AnaThe occurrence of sedimentary layers indicating high energy events is common in the continental shelves sedimentary record. Their presence has been usually related either to tsunami waves or storm waves. In both cases, the identification of the transport mechanism requires a variety of proxies. This work presents the preliminary results of the analysis of a gravity core (MW-107) collected at ca. 57 m water depth in the inner continental shelf of Quarteira (Algarve) and aims to identify potential high energy events.
- Offshore 1755 CE Lisbon Tsunami deposit in the southern portuguese continental shelfPublication . Kümmerer, Vincent; Drago, Teresa; Veiga-Pires, Cristina; Silva, Pedro; Lopes, Ana; Magalhães, Vitor; Roque, Cristina; Rodrigues, Ana Isabel; Terrinha, Pedro; Mena, Anxo; Francés, Guillermo; Kopf, Achim; Völker, David; Salgueiro, Emilia; Alberto, Ana; C. Lopes, Cristina; Costa, Pedro; Baptista, Maria AnaThe importance of tsunami hazard assessment is only possible if a complete dataset of events is available, allowing the determination of the recurrence intervals of the tsunamis adapted to local and regional conditions. One possible way to know these intervals is to study the offshore sedimentary record, looking for sediment remobilised and transported by the incoming tsunami waves and generated backwash currents. Even if these deposits are not of easy access (and not so well studied), the tsunami depositional signature has potential to be better preserved than those located onshore.
- Silves bridge geometric model via structure-from-motion: tool for heritage digital catalogsPublication . Prates, Gonçalo; Marçal Gonçalves, Marta; Lopes, Ana; Laranja, RobertoThe old bridge in Silves, Portugal, has five perfectly formed arches extending over the Arade river with about 76 meters long built of local materials. In the 14th century this structure was rebuilt on the location of a previous structure built when Silves was the Moorish capital between the 8th and 13th centuries occupation of the Algarve. Though a Roman road might have crossed this area, there is no medieval descriptions mentioning a bridge in Silves, still it is also known as the Roman bridge.After interventions in the 14th, 17th, 18th and 20th centuries, the bridge was classified as monument of public interest and became pedestrian-only and frequently evaluated for its risk of collapse. Stereo-photogrammetry is a recognized surface reconstruction tool applied for almost one century, where from several overlapping images of the surface a 3D model can be obtained. Contrasting with classical stereo-photogrammetry, Structure-from-Motion (SfM) is a nearly automated compilation of digital imagery processing strategies that solve for camera position and surface geometry using matching features identified in several images from diverse perspectives and preferably with high degree of overlap. Together with ongoing increase in computer power, SfM allowed digital stereophotogrammetry to be operative for close-range, high-resolution and non-metric overlapping digital images, and cost-effective. Applying these nearly automated strategies to digital images of the old bridge in Silves taken from the surrounding grounds, a dense point-cloud was computed providing its complete digital model allowing accurate measurements and materials visual identification, key elements for heritage digital catalogs and historical building information models.