Browsing by Author "Martins, A."
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- Adalimumab and number of previous biological disease-modifying antirheumatic drugs as predictive factors for the development of immune-mediated skin lesionsPublication . Martins, A.; Oliveira, D. Santos; Martins, F. R.; Nicolau, R.; Pinheiro, F. Oliveira; Rato, M.; Bernardo, A.; Pimenta, S.; Bernardes, M.; Costa, L.Treatment of inflammatory rheumatic diseases has dramatically changed with the introduction of biologic disease modifying anti-rheumatic drugs (bDMARDs). However, these drugs aren’t exempt from risks and skin lesions are the most frequent adverse reactions. Among the possible adverse skin reactions, immune-mediated skin lesions (IMSL) may occur. Risk factors associated with the occurrence of IMSL in rheumatic patients under bDMARDs are poorly known and studied.
- Basic Emotion Recognition According to Clinical Personality TraitsPublication . Martins, A.; Ros, Antónia; Valerio, Leticia; Faísca, LuísDisturbances in the ability to recognize emotional faces have been attributed to individuals with specific personality disorders. Considering the importance of the dimensional models of psychopathology, studies involving healthy participants are becoming increasingly relevant in the domain of personality disorders. In this context, our main goal was to assess how clinical personality traits affect the ability to recognize basic emotions in a sample of subclinical participants. Photographs of faces expressing six basic emotions (happiness, sadness, fear, anger, disgust and surprise) were presented to 72 undergraduate students (42 women
- Emotional recognition and empathy both in deaf and blind adultsPublication . Martins, A.; Faísca, Luís; Vieira, Helena; Maria Ramos Gonçalves, GabrielaStudies addressing the recognition of emotions in blind or deaf participants have been carried out only with children and adolescents. Due to these age limits, such studies do not clarify the long-term effects of vision and hearing disabilities on emotion recognition in adults. We assessed the ability to recognize basic emotions in 15 deaf adults (aged 32.4 +/- 8.1 yrs) and in 15 blind adults (48.3 +/- 10.5 yrs). Auditory and visual stimuli expressing six basic emotional states were presented to participants (Florida Affect Battery). Participants also performed an empathy test. Deaf participants showed difficulties in emotion recognition tasks compared to the typical hearing participants
- How did the AD 1755 tsunami impact on sand barriers across the southern coast of Portugal?Publication . Costa, Pedro J. M.; Costas, Susana; González-Villanueva, R.; Oliveira, M. A.; Roelvink, D.; Andrade, C.; Freitas, M.C.; Cunha, P. P.; Martins, A.; Buylaert, J.-P.; Murray, A.Tsunamis are highly energetic events that may destructively impact the coast. Resolving the degree of coastal resilience to tsunamis is extremely difficult and sometimes impossible. In part, our understanding is constrained by the limited number of contemporaneous examples and by the high dynamism of coastal systems. In fact, long-term changes of coastal systems can mask the evidence of past tsunamis, leaving us a short or incomplete sedimentary archive. Here, we present a multidisciplinary approach involving sedimentological, geomorphological and geophysical analyses and numerical modelling of the AD 1755 tsunami flood on a coastal segment located within the southern coast of Portugal. In particular, the work focuses on deciphering the impact of the tsunami waves over a coastal sand barrier enclosing two lowlands largely inundated by the tsunami flood. Erosional features documented by geophysical data were assigned to the AD 1755 event with support of sedimentological and age estimation results. Furthermore, these features allowed the calibration of the simulation settings to reconstruct the local conditions and establish the run-up range of the AD 1755 tsunami when it hit this coast (6–8 m above mean sea level). Our work highlights the usefulness of erosional imprints preserved in the sediment record to interpret the impact of the extreme events on sand barriers.
- Immune-mediated skin lesions related to biological disease-modifying antirheumatic drugs: a 22-year experience of a tertiary centerPublication . Martins, A.; Oliveira, D. Santos; Martins, F. R.; Nicolau, R.; Pinheiro, F. Oliveira; Rato, M.; Bernardo, A.; Pimenta, S.; Bernardes, M.; Costa, L.Biological disease-modifying antirheumatic drugs (bDMARDs) have revolutionized the treatment of chronic inflammatory rheumatic diseases. However, the physician and the patient should be aware of possible adverse reactions. Skin is one of the most frequent organs involved in bDMARD adverse reactions and immune-mediated skin lesions (IMSL) have rarely been described before in cohort studies and their incidence is unknown.
- Mapping gene expression in social anxiety reveals the main brain structures involved in this disorderPublication . Carvalho, Filipe Ricardo Pires de; Nóbrega, Clévio; Martins, A.Social Anxiety Disorder (SAD) is characterized by emotional and attentional biases as well as distorted negative self-beliefs. According this, we proposed to identify the brain structures and hub genes involved in SAD. An analysis in Pubmed and TRANSFAC was conducted and 72 genes were identified. Using Microarray data, from Allen Human Brain Atlas, it was possible to identify three modules of co-expressed genes from our gene set (R package WGCNA). Higher mean gene expression was found in cortico-medial group, basomedial nucleus, ATZ in amygdala and in head and tail of the caudate nucleus, nucleus accumbens and putamen in striatum. Our enrichment analysis identified the followed hub genes: DRD2, HTR1A, JUN, SP1 and HDAC4. We suggest that SAD is explained by delayed extinction of circuitry for conditioned fear. Caused by reduced activation of the dopaminergic and serotonergic systems,due diminished expectation of reward during social interactions.
- P-248 Futility and utility of two-stage hepatectomyPublication . Cunha, M.; Barros, I.; Marreiros, A.; Martins, A.; Pinto Marques, H.Meeting abstract in the European-Society-for-Medical-Oncology (ESMO) 21st World Congress on Gastrointestinal Cancer.
- Prevalence and clinical characteristics of late Onset Axial Spondyloarthritis: Results from a multicentre nationwide studyPublication . Rocha, Margarida Lucas; Torres, R.; Ramiro, S.; Castro, A. M.; Neves, A.; Martins, A.; Chícharo, A. T.; Mendes, B.; Matos, C. O.; Soares, C.; Oliveira, C. P.; Parente, H.; Gomes, J. A. M.; Luís, M.; Santos, M.; Couto, M.; Bernardes, M.; Valente, P.; Costa, R.; Sousa, S.; Branco, J.; Pimentel-Santos, F.; Sepriano, A.Axial spondyloarthritis (axSpA) typically starts before the fourth decade oflife. Consistent with that, the Assessment of SpondyloArthritis international Society (ASAS)classification criteria for axSpA should be applied only in patients with chronic back pain startingbefore 45 years of age. It has, however, been suggested that axSpA can sometimes start later in lifewith a distinctive phenotype, the so-called ‘late onset axSpA’ (lo-axSpA). There is, nevertheless, onlylimited data in support of the existence of such phenotype. We aimed to evaluate the occurrence oflo-axSpA and if these patients differ from those with early onset axSpA (eo-axSpA).
- Relationship between primary tumor location and mortality in stage II colon cancerPublication . Pinto-Torres, S.; Malheiro, M.; Rato, J.; Andre, T.; Gradil, A.; João, A.; Braga, Sofia; Xavier, A. T.; Martins, A.; Fiuza, T.
- The influence of parental variables and child behavioral inhibition on social anxiety in preschool children: The moderator effects of genderPublication . Fernandes, Catarina; Martins, A.; Santa-Rita, Andreia; Faisca, LuisThe main objective of this study was to examine how parental characteristics, such as social anxiety (SA) and parental overprotection, and child's behavioral inhibition (BI) interact and contribute to the manifestation of SA symptoms in preschoolers. Parents (Mothers: n= 319; Fathers: n= 263) of children aged between 3 and 6 years answered to self-report measures of overprotection and SA and measures of SA and BI about their children. A positive moderate direct association was observed between children's BI and children's SA, independently of gender. Overprotection arises as a mediator of the effects of the parents' social anxiety on children's SA; however, this mediation depends both on the child's and parents' gender. Only mother's SA was directly related to children's SA, independently of the gender of the child. Overall, these findings extend to preschool children the previous studies that consider parents' overprotective styles and social anxiety, as well as child's BI, the main variables underlying the SA in childhood. In addition, our results highlight the importance of considering the moderator role of gender in the origin and maintenance of SA symptoms in preschoolers.