Browsing by Author "Mazzola, Priscila Gava"
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- Pluronic® triblock copolymer-based nanoformulations for cancer therapy: A 10-year overviewPublication . de Castro, Karine Cappuccio; Coco, Julia Cedran; dos Santos, Érica Mendes; Ataide, Janaína Artem; Martinez, Renata Miliani; do Nascimento, Mônica Helena Monteiro; Prata, João; Fonte, Pedro; Severino, Patrícia; Mazzola, Priscila Gava; Baby, André Rolim; Souto, Eliana Barbosa; de Araujo, Daniele Ribeiro; Lopes, André MoreniThis paper provides a review of the literature on the use of Pluronic (R) triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic (R) triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to inno-vative examples for improving tumor cytotoxicity while reducing side effects.