Percorrer por autor "Viegas, M."
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- Changes in bone mineral density in individuals with cerebral palsyPublication . Viegas, M.; Ribeiro, L. P. V.; Pinheiro, João; Vicente, B.; Rodrigues, S. I.; Abrantes, A.According to Scheinberg, et al. (2015) citing Bianchi ML. (2013) Cerebral Palsy (CP) is one of the most prevalent diseases within those that affect bone mass, and is often related to other pathologies such as osteoporosis. According to António, D., H., et al, (2020) citing NIH, (2002); WHO, (2003) osteoporosis is a pathology that involves others and is defined by the deterioration of bone tissue. In this way, with the alterations caused in the bone tissue and with the reduced BMD values, the bones lose resistance to traumas, causing their fragility and, consequently, a greater probability of the occurrence of fractures. In this way, BMD measurement will help in the diagnosis of osteopenia/osteoporosis and in the prevention of future bone fractures. In addition to bone densitometry, there are other methods, less invasive and less expensive, that effectively analyze BMD. CP is characterized as a permanent, though not invariable, disturbance of movement and posture due to a non-progressive defect or lesion of the brain early in life. (Rosa, A.C.A. & Matos, M.R. (2017)) Depending on the area of the nervous system affected, the patient with CP presents neuromuscular alterations. Each change will compromise differently and to different degrees, affecting the functional performance of these patients.
- Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genesPublication . Conceição, N.; Cox, C. J.; Simões, B.; Viegas, M.; Cancela, LeonorChondrocyte gene regulation is important for the generation and maintenance of cartilage tissues. Analysis of the transcriptional regulation of cartilage-specific genes, encoding both collagenous and noncollagenous proteins, provides a useful strategy to identify transcription factors (TFs) that control chondrocyte specification and differentiation. Our work aims at the identification of candidate TFs important for cartilage maintenance and development through an in silico approach. In order to better define the transcriptional regulatory networks that affect chondrogenesis in zebrafish we propose a combination of comparative promoter analysis and transcription factor binding site analysis using a TRANSFAC position weight matrix search to identify cis-regulatory transcription factor binding motifs in a set of cartilage characteristic genes. With this methodology we have successfully identified several transcription factors known to be important for chondrogenesis thus validating our in silico approach.