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Browsing by Issue Date, starting with "2017-11-28"

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  • Aplicação de energias renováveis para a sustentabilidade energética de edifícios
    Publication . Cavalaria, João de Deus Dias; Conceição, E. Z. E.
    A união europeia definiu metas ambiciosas no que diz respeito ao aumento da utilização de energias renováveis. A sua utilização em edifícios, de forma a reduzir a quantidade de energia não renovável por eles consumida e em sistemas de AVAC de edifícios para o conforto térmico, pode contribuir para atingir estas metas. Neste trabalho foi efetuado um estudo que consistiu no dimensionamento de turbinas para alimentar uma moradia. Este estudo dividiu-se em duas partes. Numa primeira fase dimensionou-se duas turbinas de pequenas dimensões, uma foi testada em túnel de vento e a outra foi dimensionada tendo em consideração os resultados do teste. Numa segunda fase dimensionou-se quatro turbinas com o intuito de aplica-las em edifícios, considerando a potencia que os mesmos necessitam. Para isso utilizou-se dois perfis alares, o E231 e o NACA 0009, e uma combinação de divisões das pás em diferentes secções. Os resultados indicaram que as pás das turbinas dimensionadas com o perfil alar NACA 0009 têm melhor desempenho e que o coeficiente de potencia de cálculo (0,48) aproxima-se mais do coeficiente de potencia máximo (0,593).
    2017-11-28Master thesis Open access Show more
  • Genetic and functional analysis of specific TBX5 mutations associated with Holt-Oram Syndrome
    Publication . Varela, Débora; Cancela, Leonor; Conceição, Natércia
    Marine compounds are poorly-explored, however this area is becoming attractive and interesting because of the vast diversity of unique organisms that inhabit marine environments. Recent research has targeted compounds from marine organisms directed towards the discovery of new pharmaceuticals, nutraceuticals, cosmetics and biosensors. This monograph gives an overview of research into marine compounds for cosmetics, highlighting their effects in: photoprotection against UV radiation and associated antioxidant effects, characteristic of carotenoids, phlorotannins, carrageenans and mycosporins; antiphotoaging effects, possessed by carotenoids, mycosporins and fucoidans; and melanogenesis inhibition a notable effect of carotenoids and phlorotannins. A laboratory based study of a biosensor is reported with the view to assessing its utility in screening bioactive compounds. Extraction and screening of biomolecules remains challenging and for this reason research continues into appropriate methodologies for fast identification and extraction of bioactive compounds of marine origin. Among potential screening approaches, biosensors are new tools that can be used to evaluate the properties of biomolecules of pharmacological interest. Biosensors based on a quartz crystal microbalance (QCM), are a very promising technique for monitoring molecular interactions and provide a potential alternative to animal models. In the laboratory based study reported a QCM is used to study the interaction of thyroid hormones (THs) and transthyretin in order to infer if the same approach could be useful in marine compound evaluation. The results indicated that the QCM-I technique may a good tool to screen biochemical and biological activities of small molecules and so may be of interest in to industries such as dermocosmetics and the pharmaceutical industry.
    2017-11-28Master thesis Restricted access Show more