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  • Cognitive load balancing approach for 6G MEC serving IoT mashups
    Publication . Attanasio, Barbara; Mazayev, Andriy; du Plessis, Shani; Correia, Noélia
    The sixth generation (6G) of communication networks represents more of a revolution than an evolution of the previous generations, providing new directions and innovative approaches to face the network challenges of the future. A crucial aspect is to make the best use of available resources for the support of an entirely new generation of services. From this viewpoint, the Web of Things (WoT), which enables Things to become Web Things to chain, use and re-use in IoT mashups, allows interoperability among IoT platforms. At the same time, Multi-access Edge Computing (MEC) brings computing and data storage to the edge of the network, which creates the so-called distributed and collective edge intelligence. Such intelligence is created in order to deal with the huge amount of data to be collected, analyzed and processed, from real word contexts, such as smart cities, which are evolving into dynamic and networked systems of people and things. To better exploit this architecture, it is crucial to break monolithic applications into modular microservices, which can be executed independently. Here, we propose an approach based on complex network theory and two weighted and interdependent multiplex networks to address the Microservices-compliant Load Balancing (McLB) problem in MEC infrastructure. Our findings show that the multiplex network representation represents an extra dimension of analysis, allowing to capture the complexity in WoT mashup organization and its impact on the organizational aspect of MEC servers. The impact of this extracted knowledge on the cognitive organization of MEC is quantified, through the use of heuristics that are engineered to guarantee load balancing and, consequently, QoS.
    2021-12-28Journal article Open access Show more
  • Immunotherapy in patients with advanced non-small cell lung cancer lacking driver mutations and future perspectives
    Publication . De Mello, Ramon Andrade Bezerra; Voscaboinik, Rafael; Luciano, João Vittor Pires; Cremonese, Rafaela Vilela; Amaral, Giovanna Araujo; Castelo-Branco, Pedro; Antoniou, Georgios
    From a complete literature review, we were able to present in this paper what is most current in the treatment with immunotherapy for advanced non-small cell lung cancer (NSCLC). Especially the use of immunotherapy, particularly inhibitors of PD-1 (programmed cell death protein 1), PDL-1 (programmed cell death protein ligand 1), and CTLA-4 (cytotoxic T-lymphocyte antigen 4). Since 2015, these drugs have transformed the treatment of advanced NSCLC lacking driver mutations, evolving from second-line therapy to first-line, with excellent results. The arrival of new checkpoint inhibitors such as cemiplimab and the use of checkpoint inhibitors earlier in the therapy of advanced and metastatic cancers has been making the future prospects for treating NSCLC lacking driver mutations more favorable and optimistic. In addition, for those patients who have low PDL-1 positivity tumors, the combination of cytotoxic chemotherapy, VEGF inhibitor, and immunotherapy have shown an important improvement in global survival and progression free survival regardless the PDL-1 status. We also explored the effectiveness of adding radiotherapy to immunotherapy and the most current results about this combination. One concern that cannot be overlooked is the safety profile of immune checkpoint inhibitors (ICI) and the most common toxicities are described throughout this paper as well as tumor resistance to ICI.
    2021-12-28Journal article Open access Show more