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  • Biological activity of gold compounds against viruses and parasitosis: a systematic review
    Publication . Fonseca, Custódia; Aureliano, M.
    In this contribution, we provide an overview of gold compound applications against viruses or parasites during recent years. The special properties of gold have been the subject of intense investigation in recent years, which has led to the development of its chemistry with the synthesis of new compounds and the study of its applicability in various areas such as catalysis, materials, nanotechnology and medicine. Herein, thirteen gold articles with applications in several viruses, such as hepatitis C virus (HCV), influenza A virus (H1N1), vesicular stomatitis virus (VSV), coronavirus (SARS-CoV and SARS-CoV-2), Dengue virus, and several parasites such as Plasmodium sp., Leishmania sp., Tripanossoma sp., Brugia sp., Schistosoma sp., Onchocerca sp., Acanthamoeba sp., and Trichomonas sp. are described. Gold compounds with anti-viral activity include gold nanoparticles with the ligands mercaptoundecanosulfonate, 1-octanethiol and aldoses and gold complexes with phosphine and carbene ligands. All of the gold compounds with anti-parasitic activity reported are gold complexes of the carbene type. Auranofin is a gold drug already used against rheumatoid arthritis, and it has also been tested against virus and parasites.
    2022-05-14Journal article Open access Show more
  • Ecos da Antiguidade na Poesia Portuguesa Contemporânea: Ulisses Plurais – Memórias Míticas
    Publication . Nogueira, Adriana
    Os temas da Odisseia e de Ulisses, em particular, têm tido grande receção na poesia portuguesa contemporânea, sendo a pluralidade do herói um dos fatores da adaptabilidade do mito. Os poemas aqui tratados, centrados em Ulisses (“Ulisses”, de Jorge de Sousa Braga; “Ladainha de Ulisses”, de Nuno Júdice; “O olhar de Ulisses”, de Bernardo Pinto de Almeida) refletem esse destaque, que sublinha a sua importância na mitologia nacional, evocando memórias várias, sejam da infância, musicais, cinematográficas, políticas ou religiosas. De alguma forma, os três poemas apresentados evocam, ainda, a te mática da “Segunda Odisseia”, em que Ulisses não se conforma com ser quem é e com o regresso a uma vida que já não é a sua, partindo para uma nova demanda identitária.
    2022-05-14Journal article Open access Show more