Repository logo

Browsing by Issue Date, starting with "2023-10-26"

Filter results by year or month
Now showing 1 - 3 of 3
  • Comparing conventional and patient specific instrumentation in total knee arthroplasty: an early analysis of function and satisfaction
    Publication . Vaz Pinto, Goncalo; Dantas, Sofia Caldeira-Dantas; Bessa Magalhães, Tiago; Fontes, Ana Paula; Marreiros, Ana; Ribeiro De Sousa, João Paulo
    Background: Patient specific instrumentation (PSI) in TKA is a surgical technique created to improve the accuracy of implantation, surgical time, blood loss and workflow that has been a growing trend over the past decade. Our work aims to determine if there are improvements in patient satisfaction and functional results using PSI in comparison with conventional instrumentation (CI) in TKA. Methods: The authors evaluated 716 patients from the past 10 years that underwent TKA, either by PSI (n=456) or by CI (n=260). The authors recorded the WOMAC index, articular range of motion, and the six-minute walking test at preop and day 90 post-op. T-student and Mann-Whitney tests were used considering p<0.05. Results: The functional scores achieved 90 days after surgery were better for PSI compared to CI. The respective differences are found in the extension (p=0.022), gait distance (p=0.010) and in the pain and function WOMAC index (respectively p=0.018 and p=0.020). No statistical differences were found in satisfaction. Conclusions: 90 days after TKA, the functional scores achieved with PSI were better compared to CI. However, better results in this area did not translate to significantly higher satisfaction in the patients. There seems to be a tendency in favor of better functional results in patients that underwent TKA by PSI in comparison to those submitted to CI. These results seem to follow the tendencies demonstrated in available literature.
    2023-10-26Journal article Open access Show more
  • Projeto AVAC e simulação energética de refeitório e cozinha profissional
    Publication . Furtado, Aulânio Evandro Gomes; Lopes, João
    No âmbito do Mestrado em Engenharia Mecânica adquiriu-se conhecimentos sobre os sistemas energéticos de Aquecimento, Ventilação e Ar Condicionado (AVAC) em edifícios, por isso, optou-se por desenvolver um projeto na área do AVAC tendo a escolha recaído no refeitório da Universidade do Algarve no Campus de Gambelas. Os refeitórios de grande dimensão são espaços com especificidades próprias e com requisitos de conforto térmico e de qualidade do ar interior que os tornam grandes consumidores de energia. Assim o dimensionamento dos sistemas de AVAC deste tipo de edifício são de grande importância. O presente projeto teve por objetivo a simulação energética e o dimensionamento dos sistemas de AVAC do edifício, constituído pela zona de refeições e pela cozinha profissional. Numa primeira fase foi efetuado a simulação energética do edifício recorrendo ao programa de modelação CYPE. Após esta fase, recorrendo às cargas térmicas dos diferentes espaços foram definidos e dimensionados os vários sistemas de AVAC. Depois de conhecer as cargas térmicas para cada espaço diferenciado pela sua utilização, foram dimensionados os sistemas de climatização. Além disso foram também abordados os sistemas de ventilação e controlo de fumos para manter a qualidade do ar interior. Para concluir, foram elaborados os desenhos de execução do projeto com vários sistemas AVAC nas plantas do edifício.
    2023-10-26Master thesis Open access Show more
  • Evaluation of gold complexes to address bacterial resistance, quorum sensing, biofilm formation, and their antiviral properties against Bacteriophages
    Publication . Marques, Ana; Carabineiro, Sónia A. C.; Aureliano, M.; Faleiro, L
    The worldwide increase in antibiotic resistance poses a significant challenge, and researchers are diligently seeking new drugs to combat infections and prevent bacterial pathogens from developing resistance. Gold (I and III) complexes are suitable for this purpose. In this study, we tested four gold (I and III) complexes, (1) chlorotrimethylphosphine gold(I); (2) chlorotriphenylphosphine gold(I); (3) dichloro(2-pyridinecarboxylate) gold (III); and (4) 1,3-bis(2,6-diisopropylphenyl)imidazole2-ylidene gold(I) chloride, for their antibacterial, antibiofilm, antiviral, and anti-quorum sensing activities. Results reveal that 1 significantly inhibits Escherichia coli DSM 1077 and Staphylococcus aureus ATCC 6538, while 2, 3, and 4 only inhibit S. aureus ATCC 6538. The minimum inhibitory concentration (MIC) of 1 for S. aureus ATCC 6538 is 0.59 µg/mL (1.91 µM), and for methicillin-resistant S. aureus strains MRSA 12 and MRSA 15, it is 1.16 µg/mL (3.75 µM). For E. coli DSM 1077 (Gram-negative), the MIC is 4.63 µg/mL (15 µM), and for multi-resistant E. coli I731940778-1, it is 9.25 µg/mL (30 µM). Complex 1 also disrupts biofilm formation in E. coli and S. aureus after 6 h or 24 h exposure. Moreover, 1 and 2 inhibit the replication of two enterobacteria phages. Anti-quorum sensing potential still requires further clarification. These findings highlight the potential of gold complexes as effective agents to combat bacterial and viral infections.
    2023-10-26Journal article Open access Show more