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- Biodegradation of 17α-Ethinylestradiol by strains of Aeromonas Genus isolated from acid mine drainagePublication . Da Luz Palma, Tânia Cristina; Costa, Maria Clara17α-ethinylestradiol (EE2), a synthetically derived analogue of endogenous estrogen, is widely employed as a hormonal contraceptive and is recognized as a highly hazardous emerging pollutant, causing acute and chronic toxic effects on both aquatic and terrestrial organisms. It has been included in the initial Water Watch List. The aim of this study was to isolate bacteria from consortia recovered from mine sediments and acid mine drainage samples, both considered extreme environments, with the ability to degrade EE2. From the most promising consortia, isolates affiliated with the Aeromonas, Rhizobium, and Paraburkholderia genera were obtained, demonstrating the capability of growing at 50 mg/L EE2. Subsequently, these isolates were tested with 9 mg/L of EE2 as the sole carbon source. Among the isolated strains, Aeromonas salmonicida MLN-TP7 exhibited the best performance, efficiently degrading EE2 (95 ± 8%) and reaching concentrations of this compound below the limits of detection within 7 and 9 days. The final metabolites obtained are in accordance with those of the TCA cycle; this may indicate EE2 mineralization. As far as is known, Aeromonas salmonicida was isolated for the first time and identified in acid mine drainage, demonstrating its capacity to degrade EE2, making it a promising candidate for bioaugmentation and suggesting its possible applicability in low pH environments.
- Jaccoud’s arthropathy in osteogenesis imperfectaPublication . Martins, Frederico Rajão; Rocha, Margarida Lucas; Chícharo, Ana Teodósio; Teixeira, Vítor SilvestreType I osteogenesis imperfecta is a genetic disease associated with mutations in the pro-alpha1 chains of type 1 collagen encoder gene COL1A1. It has an autosomal dominant pattern of inheritance, and leads to reduction in the amount of structurally normal collagen and subsequently, disorders of the extracellular membrane of skin, tendons and bone.