Browsing by Issue Date, starting with "2024-05-13"
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- Determinants of citations in tourism and hospitality studiesPublication . Correia, Antónia; Rodrigues, Paulo Manuel Marques; Kozak, Metin; Raposo, PedroCitation metrics are frequently used to assess research and rank journals and researchers. Nevertheless, this is still a process with asymmetric information. Tourism research has matured within a small community and through a multidisciplinary scientific paradigm. This paper aims to understand the determinants of tourism research citation patterns. To this end, 101,968 papers within fifteen years (2004-2018) are analysed. Our empirical results suggest that authors' prestige, the multidisciplinary nature of research, and the impact factor of journals and bibliometric articles will likely increase an article's citations. This paper represents a step forward in understanding the citation formation process in tourism research.
- Multicriteria decision for selecting tourist destinations and increase its competitivenessPublication . Vanti, Adolfo; Solana-González, Pedro; Ramos, CeliaThe competitiveness of a tourist destination is related to its capacity to present products and services better than others, providing tourist experiences that meet the preferences of those who demand them. However, how tourists decide which destination to visit is a question that needs to be answered to support all destination stakeholders, and this is the aim of this research. This paper uses the Multi-Criteria Decision-Making approach to prioritise the types of tourism. The method applied is the Analytic Hierarchy Process, and the results showed the greater importance of the criteria of rest/simplicity and cultural difference. As for the tourist destinations, the most relevant in order of priority were Cruise tourism followed by Art/culture tourism, showing that these two types of tourism must be combined in a co-competition
- Maternal thyroid hormones role in zebra fish blood-hindbrain barrier developmentPublication . Trindade, Marlene Pacheco; Campinho, António do Nascimento Sequeira de JesusThyroid hormones (THs), thyroxine (T4) and 3,5,3’–triiodothyronine (T3), are key signalling molecules that regulate vertebrate development and physiology. In humans, an inadequate supply of THs during prenatal stages causes several neurological impairments, affecting a newborn’ psychomotor and cognitive development. The most severe condition results from mutations of the monocarboxylate transporter 8 (MCT8), leading to a rare X-linked neurodevelopmental disorder, the Allan-Herndon-Dudley syndrome (AHDS). In zebrafish, knockdown of the T3 exclusive membrane transporter Mct8 phenocopies the symptoms observed in AHDS patients. An impaired blood-hindbrain barrier (BHB) was observed in zebrafish but has not yet been confirmed in humans. This thesis aimed to understand how maternal T3 (MT3) through Mct8 coordinates the development of the vascular system of the zebrafish hindbrain. Transcriptome analysis of 25 hours post fertilisation (hpf) CTRMO vs MCT8MO zebrafish embryos revealed that expression of several genes of the important angiogenic Vegf pathway was significantly regulated by MT3. At the cellular level, specific vegfaa signalling juxtaposed to the developing central arteries (CtAs) was identified and vegfaa-165 mRNA rescues the majority of CtAs in MCT8MO zebrafish embryos. To identify the source of hindbrain vegfaa and, consequently, the cell identity dependent on MT3 signalling, neural cell markers were analysed. This revealed that pax8 inhibitory interneurons and cpne4 intrinsic digit-innervating motor neurons were under MT3 regulation but were not responsible for CtA development. pax6a neural progenitor cells (NPCs) were the source of hindbrain vegfaa, and a correlation between these cells and the migratory behaviour of the CtAs was found. Colocalisation analysis of pax6a NPCs with thraa, thrab and mct8 demonstrated that these cells were regulated in a cell-autonomous way and showed that the spatiotemporal expression could be an indicator of the timely sprouting of each CtA during BHB development. Finally, pax6a loss-of-function CRISPR/Cas9 zebrafish embryos had a similar hindbrain vascular impairment as the MCT8MO zebrafish embryos, confirming that pax6a NPCs were the cells responsible for CtA ingression into the hindbrain. In conclusion, MT3 via Mct8 is important for the survival and proliferation of pax6a NPCs, which are the instructing source of vegfaa necessary for the timely development of the BHB CtAs.