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- Selective synthesis of 3-(1H-Tetrazol-5-yl)-indoles from 2H-Azirines and ArynesPublication . Grosso, Carla; Alves, Cláudia; Sase, Terver J.; Alves, Nuno G.; Cardoso, Ana L.; Melo, Teresa M. V. D. Pinho e; Lemos, AmericoA new selective synthetic approach to indole derivatives bearing a tetrazole moiety has been developed. Arynes, generated in situ from o-(trimethylsilyl)aryl triflates and KF, reacted smoothly with 2-(2-benzyl-2H-tetrazol-5-yl)-2H-azirines to give 3-(2-benzyl-2H-tetrazol-5-yl)-indole derivatives with high selectivity. Deprotection of the tetrazole moiety gave 3-(1H-tetrazol-5-yl)-indole derivatives.
- Psychodermatology of Chronic Pruritus: an overview of the link between itch and distressPublication . Ferreira, Bárbara R.; Katamanin, Olivia M.; Jafferany, Mohammad; Misery, LaurentChronic pruritus (CP) is defined as an unpleasant sensation causing a desire to scratch and lasting > 6 weeks. It has a multifactorial etiology but is more frequently associated with chronic inflammatory dermatoses and systemic disorders. Psychogenic pruritus and neurological disorders are other less common etiologies, while, in some patients, it is idiopathic. CP appears to be processed by non-histaminergic pathway, contributing to its complexity and therapeutic challenge. Moreover, regardless of the etiology, it is multidimensional, including cognitive, motivational and affective components. There is a close link between psychological distress and pruritus, with particular clinical expression in chronic inflammatory dermatoses, involving the activation of the hypothalamic-pituitary-adrenal axis (and its cutaneous equivalent), the sympathetic nervous system, the release of hormones and peptides, the role of immune cells (T and B cells, macrophages) and immune-related cells in the skin (mast cells, dendritic cells and keratinocytes). Moreover, there is strong evidence that psychological factors influence the experience of pruritus. CP can also cause psychiatric disorders, including but not limited to anxiety and depression, and also lead to significant quality of life (QoL) impairment. Thereby, although a psychodermatological assessment should ideally be carried out in the context of a specific psychodermatology consultation, a brief mental health assessment could be part of the general dermatological approach to these patients. Considering that mental health, QoL and pruritus are closely linked, psychotherapeutic interventions and/or psychotropic drugs should thus be considered in some patients as an adjunct to the pharmacological treatment of CP.
- Long-lasting latent neuroschistosomiasis in a nonendemic country: a case reportPublication . Alves, Janice; Bonifácio, Gonçalo V.; Vieira, Rodrigo; Militão, André; Guerreiro, RuiNeuroschistosomiasis is an uncommon yet serious cause of myelopathy. Schistosoma mansoni infection triggers a granulomatous immune response by the human host, resulting in many clinical presentations, depending on the size of the granuloma and its location. The parasitic infection can remain silent for a long period, and this diagnosis should be considered if there is a history of previous exposure in endemic regions. Prompt diagnosis and treatment are crucial for a favorable outcome, minimizing the risk of permanent neurological disability. A case of medullary neuroschistosomiasis is presented, many years after exposure, in a patient who presented with low back pain, rapidly progressing to paraparesis with significant gait impairment. Magnetic resonance imaging findings revealed extensive medullary involvement from the conus all the way to the cervical spine level. After ruling out other causes of myelopathy and considering previous history, total anti-Schistosoma antibodies were tested and detected, confirming the diagnosis. Steroids and schistosomicides were started, with remarkable clinical and imagiological improvement. The patient regained normal muscle strength, gait, and functional independence in the following six months.
- Experience Co-CreationPublication . Yang, Juan; Campos, Ana Cláudia; Liu, Biqiang; Moyle, Brent; Kralj, Anna; Le, Truc H.Co-creation experiences are psychologically complex phenomena. This chapter discusses how cognitive psychology can add value to the co-creation of experiences. There are different meanings of co-creation and here the focus is on the customer’s mental experience. This chapter analyses the theoretical underpinnings of co-creation and discusses key dimensions of the concept from a cognitive perspective, highlighting the importance of attention and active involvement. Furthermore, it discusses how technologies (augmented reality, robotics, intelligence systems) can prompt experience co-creation. Finally, this chapter examines the literature of co-creation and experiential learning overlap in knowledge building. Opportunities for future empirical research in this area are suggested.
- The cognitive wave: major conceptsPublication . Scott, Noel; Moyle, Brent; Campos, Ana Cláudia; Skavronskaya, Liubov; Liu, BiqiangThis chapter discusses the main psychological paradigms used in the past 100 years, psychodynamism, behaviourism and cognitivism based on an information processing paradigm, and later cognitivism based on complex interactive mental processes. It briefly introduces the main concepts of later cognitive psychology: consciousness, sensation, perception, attention, emotion and memory. Each of these concepts will be discussed in detail in later chapters along with their application to tourism. One basic assumption of cognitive psychology is that the brain emerged through evolution and has survival value. However, this means that the brain is not a unified designed organ but has layers of development, one building on the others.
- Updating tourism theory: The S-O-R ModelPublication . Scott, Noel; Moyle, Brent; Campos, Ana Cláudia; Skavronskaya, Liubov; Liu, BiqiangThis chapter presents a case for updating the use and development of psychological theory in tourism through an examination of the psychological stimulus-organism-response (S-O-R) model. The historical development and the criticism of the model has been addressed. A revised version of the model is provided based on importing new theoretical knowledge from the original discipline. This chapter argues that with an explicit focus on tourism psychology, there is some evidence to suggest that tourism theory may benefit from adopting theory from the parental discipline rather than inventing its own. Future research can address other examples of imported theories and to further examine mechanisms for this knowledge transfer and update from original disciplines relevant to the study of tourism.
- Cognitive science and tourismPublication . Scott, Noel; Moyle, Brent; Campos, Ana Cláudia; Skavronskaya, Liubov; Liu, BiqiangThis chapter introduces the cognitive paradigm. The concept of translation and associated problems is discussed. Several arguments for the adoption of a cognitive-based social sciences are provided. A brief history of the term cognition is provided and the origin of theory in tourism discussed. Justifications for the use of cognitive psychology in the field of tourism are provided. These include the (mostly) hedonic and hence emotional nature of tourism experiences, the novelty of travel outside one’s usual environment, the importance of imagining, daydreams, emotions and desire for travel decisions and the importance of autobiographical memories because of travel.