Browsing by Issue Date, starting with "2024-07-01"
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- Drug-associated acute kidney disease – data from a world pharmacovigilance databasePublication . Baptista, Alexandre; Marreiros, Ana; Macedo, Ana; Coelho, AndréBackground Drugs are a frequent cause of nephrotoxicity, especially in the context of acute kidney disease (AKD), with a significant number of cases being drug-associated. The WHO's VigiBase is a powerful tool for identifying drugs described and associated with the development of AKD. Methods We retrieved data from the period 1968 to 2022 regarding notifications of adverse drug reactions (ADR). The extracted medications were evaluated for their nephrotoxicity based on the bibliographic score (BS) developed through pre-selected references. The main medications involved were classified as 'non-nephrotoxic', 'potentially nephrotoxic', and 'nephrotoxic'. We utilized the IC025 and reporting odds ratio (ROR) disproportionality indexes to study the relationship between medications and the odds of being included in an AKD notification. Results During the period, a total of 33,932,051 notifications were obtained, revealing 435,677 cases related to drug-associated AKD following MedDRA term filtering, predominantly affecting males aged 45-64. We identified 8,991 active ingredients or suspected combinations associated with AKD development, with the ATC class A - Alimentary Tract and Metabolism being the most frequently described. Among the medications most strongly associated with this phenotype, classes J and N stood out. Among the most notable medications collected, 8.3% were classified as "non-nephrotoxic," 16.7% as "potentially nephrotoxic," and 75% as "known nephrotoxic." Notable active ingredients included cobicistat + elvitegravir + emtricitabine + tenofovir disoproxil (IC025 8.7; ROR 786.96), inotersen (IC025 7.7; ROR 604.57), emtricitabine + tenofovir disoproxil (IC025 7.9; ROR 432.36), esomeprazole (IC025 6.8; ROR 184.23), and pantoprazole (IC025 6.3; ROR 109.86), with proton pump inhibitors dominating the top four positions among the most frequently involved medications. Conclusion AKD is a frequent adverse reaction in VigiBase, with a significantly high reported mortality rate. Evaluation of the notifications revealed medications with a high disproportionality index and a strong association with AKD. We also highlight the potential nephrotoxic role of less suspected medications. This study emphasizes the need to consider AKD as a condition potentially associated with iatrogenic etiology, highlighting various medications and their respective involvement in the various possible manifestations of AKD.
- Harnessing AI and NLP tools for innovating brand name generation and evaluation: a comprehensive reviewPublication . Lemos, Marco; Cardoso, Pedro; Rodrigues, JoaoThe traditional approach of single-word brand names faces constraints due to trademarks, prompting a shift towards fusing two or more words to craft unique and memorable brands, exemplified by brands such as SalesForce (c) or SnapChat (c). Furthermore, brands such as Kodak (c), Xerox (c), Google (c), H & auml;agen-Dazs (c), and Twitter (c) have become everyday names although they are not real words, underscoring the importance of brandability in the naming process. However, manual evaluation of the vast number of possible combinations poses challenges. Artificial intelligence (AI), particularly natural language processing (NLP), is emerging as a promising solution to address this complexity. Existing online brand name generators often lack the sophistication to comprehensively analyze meaning, sentiment, and semantics, creating an opportunity for AI-driven models to fill this void. In this context, the present document reviews AI, NLP, and text-to-speech tools that might be useful in innovating the brand name generation and evaluation process. A systematic search on Google Scholar, IEEE Xplore, and ScienceDirect was conducted to identify works that could assist in generating and evaluating brand names. This review explores techniques and datasets used to train AI models as well as strategies for leveraging objective data to validate the brandability of generated names. Emotional and semantic aspects of brand names, which are often overlooked in traditional approaches, are discussed as well. A list with more than 75 pivotal datasets is presented. As a result, this review provides an understanding of the potential applications of AI, NLP, and affective computing in brand name generation and evaluation, offering valuable insights for entrepreneurs and researchers alike.
- Ultrasonographic evaluation of the Patellar Tendon in cyclists, volleyball players, and non-practitioners of sports—The influence of gender, age, height, dominant limb, and level of physical activityPublication . Pissarra, Ângela; Ribeiro, Luís Pedro; do Espírito Santo Rodrigues, Sónia IsabelThis study was based on the ultrasound evaluation of the patellar tendon dimensions in the anteroposterior and transversal approaches in sports practitioners (cyclists and volleyball players) and non-sports practitioners. Relationships between the patellar tendon length, width, and thickness with gender, age, height, the dominant limb, and level of physical activity were evaluated. The samples included cyclists, volleyball players, and non-sports practitioners between 15 and 25 years old. Individuals were positioned supine with 30 degrees of knee flexion for bilateral measurements. Sports practitioners presented with an increased patellar tendon length and thickness. There were significant differences bilaterally between sports and non-sports practitioners (p < 0.003). The three dimensions of the patellar tendon of both limbs presented correlations with the male gender (0.336 < r < 0.601), and values of moderate-to-strong intensity in the length of the patellar tendon was directly proportional to height (0.520 < r < 0.601). There was a significant difference between the patellar tendon width and age (p < 0.025). Regarding the level of physical activity, significant differences were found between low and high levels in the three dimensions bilaterally (p < 0.004). The study results indicate that gender, age, height, and level of physical activity impact patellar tendon dimensions. However, there are no associations with the dominant limb.
- Surgical technique and chronic postoperative inguinal pain in patients undergoing open Inguinal Hernioplasty in Portugal: a prospective multicentric cohort studyPublication . Santos, Irène; Simões, Joana F. F.; Dias, Cláudia Camila; Alves, Mafalda Sampaio; Azevedo, José; Cunha, Miguel; João, Ana Alagoa; Nobre, José Guilherme; Picciochi, Maria; Soares, António Sampaio; Vieira, Bárbara; Peyroteo, MarianaIntroduction: Evidence about the advantage of Lichtenstein’s repair, the guidelines’ recommended technique, is scarce regarding postoperative chronic inguinal pain (CPIP). The primary aim of this study was to compare CPIP in patients undergoing Lichtenstein versus other techniques. Methods: Prospective multicentric cohort study including consecutive adults undergoing elective inguinal hernia repair in Portuguese hospitals (October - December 2019). Laparoscopic and mesh-free hernia repairs were excluded. The primary outcome was postoperative pain at three months, defined as a score of ≥ 3/10 in the European Hernia Society Quality of Life score pain domain. The secondary outcome was 30-day postoperative complications.Results: Eight hundred and sixty-nine patients from 33 hospitals were included. Most were men (90.4%) and had unilateral hernias (88.6%). Overall, 53.6% (466/869) underwent Lichtenstein’s repair, and 46.4% (403/869) were treated with other techniques, of which 83.9% (338/403) were plug and patch. The overall rate of CPIP was 16.6% and 12.2% of patients had surgical complications. The unadjusted risk was similar for CPIP (OR 0.76, p = 0.166, CI 0.51 - 1.12) and postoperative complications (OR 1.06, p = 0.801, CI 0.69 - 1.60) between Lichtenstein and other techniques. After adjustment, the risk was also similar for CPIP (OR 0.83, p = 0.455, CI 0.51 - 1.34) and postoperative complications (OR 1.14, p = 0.584, CI 0.71 - 1.84).Conclusion: The Lichtenstein technique was not associated with lower CPIP and showed comparable surgical complications. Further investigation as-sessing long term outcomes is necessary to fully assess the benefits of the Lichtenstein technique regarding CPIP.