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  • Serum neutrophil biomarkers to predict crohn's disease progression and infliximab treatment outcomes
    Publication . Magalhaes, D.; Santiago, M.; Patita, M.; Arroja, B.; Lago, P.; Rosa, I.; Sousa, Helena Tavares; Ministro, P.; Mocanu, I.; Vieira, A.; Castela, J.; Moleiro, J.; Roseira, J.; Eugenia, C.; Sousa, P.; Portela, F.; Correia, L.; Dias, S.; Afonso, J.; Danese, S.; Peyrin‐Biroulet, L.; Dias, C. C.; Magro, F.
    Background and aims: Predicting the treatment outcomes of biological therapies is an unmet need in Crohn's Disease. In this study, we explored the potential of serum neutrophil-related biomarkers to predict infliximab therapeutic results and disease progression in Crohn's Disease patients, over a 2-year period, in a real-world setting. Methods: The study included 100 asymptomatic Crohn's Disease patients in the IFX maintenance phase from the prospective, observational, multicenter DIRECT study. Patients were categorized according to a composite outcome reflecting progression that included surgery, hospitalizations, new fistulae, abscess or stricture, and drug treatment escalation. Serum neutrophil elastase, lipocalin-2, lactoferrin, and resistin (non-neutrophil control) were analyzed via multiplex magnetic bead assays at multiple touchpoints. Fecal calprotectin was assessed by ELISA. Results: Over up to 2 years of follow-up, serum biomarkers did not differentiate between the composite outcome groups, whereas fecal calprotectin was significantly higher in patients with worse outcomes. During the infliximab maintenance phase, there was a significant, sustained reduction of neutrophil elastase (p < 0.001), lipocalin-2 (p < 0.001), and lactoferrin (p < 0.001), but not of resistin, despite stable neutrophil levels. Correlations between NE and NGAL levels were strong (Pearson correlations 0.75-0.85); all other correlations were of small magnitude. Conclusion: Our real-world data do not support using serum neutrophil elastase, lipocalin-2, or lactoferrin concentrations as predictors of treatment outcomes or disease evolution in infliximab -treated Crohn's Disease patients. On the other hand, the sustained decrease in biomarkers over time suggests that neutrophil stabilization might be an additional infliximab mechanism of action.
    2024-12-08Artigo científico Acesso aberto Ver mais
  • A cost-effective solution for predictive maintenance in industrial pumping systems
    Publication . Brito, Sergio; Azinheira, Gonçalo; Semião, Jorge; Sousa, Nelson
    This paper presents a cost-effective, Internet of Things (IoT)-based solution for predictive maintenance (PdM) in industrial pumping systems. The proposed system integrates custom-built hardware with machine learning (ML) algorithms to monitor and detect anomalies in real-time. The innovation of the system lies in its non-intrusive design, ease of installation, and adaptability to a variety of industrial environments, providing a practical, low-cost alternative to traditional PdM solutions. Detailed discussion is provided on the hardware component selection, which prioritizes affordability without sacrificing performance, as well as the machine learning strategies used for anomaly detection. Preliminary results from laboratory and field testing demonstrate the system’s potential for reducing downtime and maintenance costs, with a focus on extending the application to broader industrial contexts.
    2024-12-08Documento de conferência Acesso restrito Ver mais