Browsing by Issue Date, starting with "2025-03-19"
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- The role of management on gender (in) equality and offensive behaviors in higher education: addressing work-life balance culture and work-family conflictPublication . Sobral, Tiago; Vieira dos Santos, Joana; Giger, Jean-Christophe; Teodosio, MariaDespite the numerical predominance of women in higher education institutions (HEIs), significant underrepresentation in academic and leadership positions persists, highlighting ongoing gender inequalities. This study examines the role of management in addressing gender disparities and offensive behaviors within a Portuguese public HEI, using psychosocial safety climate (PSC) theory as a conceptual framework. We conducted two studies involving 405 participants-students and staff-to assess perceptions of gender equality and the impact of a management-promoted work-life balance culture (WLBC). Our findings reveal that active management engagement in gender equality is significantly correlated with reduced perceptions of gender inequality among both students and staff. However, gender differences emerged, with female participants reporting a higher perception of gender inequality. Despite notable improvements in gender perceptions, the reduction in reported offensive behaviors was not statistically significant, underscoring the complexity of addressing such behaviors through management interventions alone. Mediation analyses indicated that WLBC indirectly influences perceptions of gender inequality and offensive behaviors through its impact on work-family conflict (WFC), highlighting WFC as a significant mediator. This research underscores the importance of a proactive managerial approach in fostering an inclusive academic environment and demonstrates the nuanced role of WLBC and WFC in mediating gender equality outcomes.
- A comprehensive comparative study of quick invariant signature (QIS), dynamic time warping (DTW), and hybrid QIS + DTW for time series analysisPublication . Shahbazkia, Hamid Reza; Khosravani, Hamid Reza; Pulatov, Alisher; Hajimani, Elmira; Kiazadeh, MahsaThis study presents a comprehensive evaluation of the quick invariant signature (QIS), dynamic time warping (DTW), and a novel hybrid QIS + DTW approach for time series analysis. QIS, a translation and rotation invariant shape descriptor, and DTW, a widely used alignment technique, were tested individually and in combination across various datasets, including ECG5000, seismic data, and synthetic signals. Our hybrid method was designed to embed the structural representation of the QIS with the temporal alignment capabilities of DTW. This hybrid method achieved a performance of up to 93% classification accuracy on ECG5000, outperforming DTW alone (86%) and a standard MLP classifier in noisy or low-data conditions. These findings confirm that integrating structural invariance (QIS) with temporal alignment (DTW) yields superior robustness to noise and time compression artifacts. We recommend adopting hybrid QIS + DTW, particularly for applications in biomedical signal monitoring and earthquake detection, where real-time analysis and minimal labeled data are critical. The proposed hybrid approach does not require extensive training, making it suitable for resource-constrained scenarios.
- Study of BUB1 functions in the neurodevelopmentPublication . Silva, Anita Ferreira Triguinho da; Carvalhal, Sara; Calado, SofiaBudding uninhibited by benzimidazole 1 (BUB1) is a kinase protein essential for proper chromosome segregation. Recently, we identified two biallelic BUB1 mutations linked to primary microcephaly, a rare condition causing reduced head size. The transmission pattern of BUB1’s individuals was consistent with the Autosomal Recessive Primary Microcephaly 30 (MCPH30). The present thesis aimed to understand how the BUB1 protein functions during human neurodevelopment, and how, when affected, it leads to microcephaly. We successfully generated a new induced pluripotent stem cells (iPSCs) line from patient 2’s fibroblasts. Two clones - clone 4 (C4) and clone 7 (C7) - were characterised by standard norms. Both showed pluripotency and the ability to differentiate in cells from all germ layers. However, while C4 had a diploid karyotype, C7 held trisomy on chromosome 8. To evaluate BUB1’s role in neurodevelopment, wild-type iPSCs were differentiated in neuro progenitor cells (NPCs) and then submitted to differentiation and maturation steps. Our findings reveal that when NPCs were treated with the BUB1 inhibitor drug, BAY1816032, they could not eliminate the signal for the main substrate of the BUB1 kinase, the phosphorylation on H2A-T120 (pH2A-T120), as demonstrated in somatic cells. However, pH2A-T120 levels on forebrain cells were sensible to BAY1816032. These cells hold several morphological modifications. In addition, diploid C4 iPSCs were differentiated into NPCs. However, C4-NPCs exhibited poor stability under multipotent conditions. Additionally, C4-forebrain cells also displayed morphological changes. Previous lab results showed that BAY1816032-treatment induced microcephaly in chicken embryos. However, our preliminary study revealed that microcephalic size depends on the developmental stage. This project successfully developed a new cell line for studying BUB1, made available to the community (Ferreira et al., 2024). And, despite preliminary, our overall results support BUB1's crucial role in NPCs maintenance and proper forebrain neurodevelopment.
- "Self is a Process" (C.G. Jung) O processo de criação enquanto constituição de subjetividade na relação com os outrosPublication . Lissy, Nicole; Tavares, Mirian; Salles, CecíliaO foco do meu trabalho é a análise de um projeto de autoria, contextualizado na afinidade de outros projetos artísticos, com o objetivo de contribuir para o debate académico sobre processos de criação, na perspetiva de criar o começo de uma investigação multidisciplinar que contribua para uma nova reflexão, tanto no pensamento artístico, como no pedagógico. As investigações existentes deixam clara a natureza complexa desta reflexão, e a presente dissertação pretende contribuir para as recentes discussões, tendo consciência que sempre será apenas um primeiro passo para a construção de eventuais futuras investigações. Tal como em processo criativo, este processo de investigação nunca apresentará um resultado acabado, mas um resultado que poderá ser o início ou uma continuação de um caminho de investigação teórico-prática multidisciplinar. Utilizo perspetivas teóricas encontradas na semiótica e na constituição de subjetividade na relação com o outro para tratar o processo de criação como fenómeno imerso nas relações e interações de um sujeito em comunidade. A ação artística torna-se presença em diferentes contextos espaço-temporais e materializa-se em forma de desenho, enquanto dispositivo para arquivo de memória de encontros entre sujeitos. Privilegia-se uma abordagem interdisciplinar, que concilia conhecimento académico e práticas artísticas, explorando as interações como não-lineares e geradoras de impulsos criativos. O presente trabalho sugere possíveis caminhos para uma reflexão sobre o retrato enquanto desenho abstrato e arquivo de memória de momentos de interação que possam formar um ponto de partida para uma reflexão sobre a ideia de processo de criação e a implicação que esta ideia tem no desenvolvimento psicológico do indivíduo (criativo) em comunidade. Encontro na crítica dos processos de criação o suporte necessário e recorro a literatura de C.G. Jung e Garald Hüther para compreender melhor o processo de criação enquanto desenvolvimento psicológico na interação com outros, e enquanto constituição da subjetividade. Apresento aqui uma tentativa de deixar um impulso para uma reflexão mais profunda nas consequências que estas ideias possam ter no nosso pensar artístico e pedagógico