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- Pregnancy outcomes in systemic sclerosis: experience of a rheumatology-obstetric multidisciplinary clinicPublication . Chícharo, Ana Teodósio; Lopes, Ana Rita; Barreira, Sofia; Martins, Patrícia; Machado, Ana Rita Cruz; Pinto, Luísa; Capela, SusanaSystemic sclerosis (SSc) is a rare multisystemic connective tissue disease (CTD). It is mainly characterized by progressive fibrosis and non-inflammatory vasculopathy. Women diagnosed with SSc seem to be at increased risk of developing adverse pregnancy outcomes (APO), but maternal and perinatal outcomes remain poorly understood in these patients, with no data yet available from Portuguese centers.
- Impact of elexacaftor/tezacaftor/ivacaftor on the small airways in cystic fibrosisPublication . Silva, Sofia Campos; Barroso, Andreia; Cunha, Maria; Fragoso, Elsa; Azevedo, PilarObjective: To evaluate the impact of the elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) combination on the small airways in adults with cystic fibrosis (CF), a genetic disorder that primarily affects the respiratory system, leading to progressive lung disease. In CF, the small airways play a critical role, contributing to chronic symptoms such as cough, sputum production, and dyspnea. Methods: This was a single-center, retrospective observational study of adults with CF treated with ELX/TEZ/IVA for 12 months. We compared the patients who were homozygous for the F508del mutation of the CF transmembrane conductance regulator (CFTR) gene with those who were heterozygous for that mutation, in terms of lung function outcomes (FEV1, FEF25-75%, and the RV/TLC ratio) and the extent of non-homogeneous ground-glass opacity. Among the patients within the cohort, the same parameters were evaluated separately in those who had advanced lung disease and in those who had previously undergone CFTR modulator therapy. Results: There was a significant post-treatment improvement in lung function, with a median increase of 0.42 L/s in the FEF25-75% (p < 0.001) and a 5% reduction in the mean RV/TLC ratio (p < 0.001). There was a trend toward a higher improvement the F508del homozygous patients. A significant reduction in non-homogeneous ground-glass opacity was observed in 79.5% of the patients. Among the patients with advanced lung disease, there were notable post-treatment improvements in all of the parameters assessed. Conclusions: Our results highlight the positive impact that ELX/TEZ/IVA treatment can have on small airway function in patients with CF, with potential benefits even for those with advanced lung disease. Further research is needed in order to evaluate the long-term effects of this treatment and its relationship with patient-reported outcomes.
- Impact of bariatric and metabolic surgery on sarcopenia-related parameters according to the EWGSOP2 consensus criteria in persons living with obesityPublication . Cardoso, Paulo Alexandre e Castro; Santos, Tânia V.; Ramon-Krauel, Marta; Pais, Sandra; De Sousa-Coelho, Ana LuísaAlthough bariatric and metabolic surgery (BS) has proved effective in the treatment of obesity based on the reduction in fat mass and the remission of comorbidities, there is also loss of lean mass after BS which could compromise muscle functionality. According to the European Working Group on Sarcopenia in Older People (EWGSOP), sarcopenia is a disease associated with loss of muscle mass, strength, and function. Through a comprehensive review of the literature, we identified a range of studies focusing on evaluating sarcopenia-related parameters according to the EWGSOP2 consensus criteria, before and after BS. Although most studies reported reductions in skeletal muscle mass and absolute muscle strength after surgery, improvements in muscle functionality were generally achieved, independent of the type of BS.
- A bibliometric analysis: wine tourism in the sectorPublication . Gómez-Carmona, Diego; Marín-Dueñas, Pedro Pablo; Correia, Marisol B.; Escobar, Marta Toribio; de Matos, Nelson Manuel da Silva; Cruces-Montes, Serafín JesúsThe term “wine tourism” was first used in 90’s from Australia. The definition of ecotourism has been studied by many academics throughout its history, reaching the conclusion that it is the activities carried out by people outside their usual environment in a given period of time related to the viticulture of the environment and wine. This study aims to enhance knowledge in the wine tourism field by employing bibliometric methods to quantitatively analyze its evolution over the past two decades. This analysis shows that from 2019 onwards, publications increased considerably, reaching a peak in 2020, mostly (linking with COVID-19 lockdown). In the areas of geography and economics, as research in the area of tourism is still very recent. The conceptual analysis shows the variety of terms used by researchers and how they have evolved over time, the most commonly used being "touristic" and "vineyard", with others appearing such as "meal" connected to "winery waste" or "tourism development", which are more akin to current management.