Browsing by Issue Date, starting with "2025-10-11"
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- Innovative approaches to mitigating microplastic pollution in effluents and soilsPublication . Magalhães, Solange; Alves, Luís; Medronho, Bruno; Svanedal, Ida; Norgren, Magnus; Rasteiro, Maria GraçaMicroplastic pollution represents a significant environmental challenge, as microplastics accumulate in effluents and soils, causing serious risks to ecosystems and human health. Efficient removal of these contaminants is essential to mitigate their potential adverse effects. This review summarizes and critically analyses current methods for the removal of microplastics from effluents and soils, focusing on their effectiveness, advantages, and limitations. Conventional techniques—including filtration, flotation, chemical coagulation, flocculation, and adsorption—are discussed in the context of wastewater treatment and soil remediation. Emerging approaches, such as flocculation processes with special focus on the application of bio-based flocculants, are also highlighted as promising solutions. Key challenges in microplastic removal, including the diversity of microplastic types, their small size, and the complexity of environmental matrices, are addressed. This work intends to contribute to the urgent need for further research to develop more efficient and sustainable strategies for microplastic removal from environmental systems.
- Unraveling the heterogeneity of electoral abstention: profiles, motivations, and paths to a more inclusive democracy in PortugalPublication . Almeida, Nuno; Giger, Jean-ChristopheElectoral abstention is a growing phenomenon in contemporary democracies, raising concerns about the representativeness and legitimacy of elected governments, particularly in Portugal where youth participation remains low. This study explores the heterogeneity of non-voting behavior by comparing insights from voters and non-voters through online focus groups. Employing content analysis on qualitative data from 42 participants, the research identifies distinct non-voter profiles, systemic barriers, and potential pathways to increased participation. Key findings reveal heterogeneous abstainer types—including disbelieving citizens, disinterested youth, pragmatic non-voters, and protest non-voters— driven by distrust, practical obstacles, and insufficient political literacy. Despite non-voting, many express conditional willingness to participate in high-stakes scenarios or following reforms. The study concludes that addressing these barriers requires holistic measures, such as enhanced civic education, technological voting modernization, and improved political representation, to foster trust and democratic engagement. These insights offer actionable recommendations for policymakers to enhance voter turnout and strengthen democratic legitimacy.
- A new variant in the NALCN channel is responsible for cerebellar ataxia and cognitive impairmentPublication . Cabrita Pinto, Rute Luísa; Fancellu, Roberto; Markushi, Tiziana Benzi; Viaggi, Silvia; Testa, Barbara; Conteduca, Giuseppina; Fitzsimmons, Lane; Coviello, Domenico; Covone, Angela ElviraCLIFAHDD syndrome (OMIM # 616266) is a rare neurodevelopmental disorder caused by mutations in the NALCN gene. It is characterized by hypotonia, developmental delay, and congenital contractures of the limbs and face. We report a 33-year-old Italian woman with a mild form of CLIFAHDD who exhibited early-onset language difficulties and mild intellectual disability and later developed gait and balance impairments in adulthood. Whole Exome Sequencing (WES) identified a novel missense variant c.1514A>T; p.(Lys505Met) in the NALCN gene. The allele frequency of this variant is not detected (MAF = 0.0), the variant is classified as likely pathogenic according to ACMG criteria, and predicted to be probably damaging by PolyPhen-2. It affects a critical residue within the second pore-forming domain of the NALCN channel, potentially altering lipid interactions and channel regulation. Sanger sequencing and segregation analysis confirmed the variant to be heterozygous and de novo. The patient's milder symptoms and later onset, compared to severe pediatric cases, suggest that the clinical spectrum of CLIFAHDD syndrome may be broader than previously recognized. These findings underscore the potential influence of mutation location on disease presentation and severity.