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- University success of graduates with disabilities in Portugal: analysis of personal factors and resiliencePublication . Fernández, Almudena Cotán; Martins, Maria Helena; Alexandre Borges Santos Terremoto, Maria Leonor; Díez, Anabel MoriñaThis paper aims to explore, from an ecological approach, the perception of the concept of academic success and the personal factors that contribute to the university success of graduates with disabilities. This paper focuses on the personal factors of academic success based on the experiences and perspectives of graduates with disabilities. The study adopted a phenomenological approach using semi-structured interviews. The data were collected at a Portuguese University in southern Portugal and analysed using an ad hoc inductive and qualitative coding system. The results reveal the diversity of perceptions about academic success and the importance of resilience, autonomy, and self-determination. These data contrast the conventional notion of success focused exclusively on academic performance and highlight to recognise the diverse contributions of these students to the university environment. Regarding personal factors, resilience is a recurring factor among participants. Adapting and persevering in the face of challenges was essential for success, alongside autonomy, self-efficacy, and self-determination.
- CRISPR-based functional genomics in pluripotent stem cellsPublication . Zahedi, SetarehThe integration of CRISPR-based functional genomics with pluripotent stem cell (PSC) technologies has been recognized as a transformative approach for investigating gene function, modeling human disease, and advancing regenerative medicine. The aim of this review is to provide a comprehensive evaluation of recent developments in CRISPR-Cas platforms, including gene knockouts, base and prime editing, and CRISPR activation or interference (CRISPRa/i), as applied to PSC systems. Studies employing human PSCs, including embryonic stem cells and induced pluripotent stem cells, have been examined to summarize methodologies for genome-wide screening, lineage tracing, and therapeutic engineering. Advances in editing efficiency, delivery strategies, and genomic safety have been reported, while limitations persist in the form of off-target modifications, epigenetic variability, and cell-type-specific responses. Notable applications include the generation of immune-evasive PSC lines, the development of organoid models for physiological and pathological studies, and the implementation of phenotypic screening for disease-relevant traits. Collectively, these technological and methodological advancements have established functional genomics of PSC-CRISPRSPR as a versatile and powerful framework for elucidating fundamental aspects of human biology, dissecting complex traits, and accelerating the translation of discoveries from experimental research to clinical implementation.