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- Positive residential care integration scale: Portuguese adaptation and validationPublication . Simão, Ana; Martins, Cátia; Ratinho, Elias; Kothari, Brianne H.; Nunes, CristinaYoung people in residential care settings hold distinct preferences regarding their relationships with key adults, including caseworkers and caregivers. However, their perspectives are not consistently assessed or effectively integrated into case planning. Evaluating this integration is essential for fostering positive adjustment and placement stability. Given that residential care represents the predominant child welfare intervention in Portugal, this study adapts and validates an existing instrument for use with youth in residential care institutions, providing evidence of its validity and reliability. Self-report questionnaires—the Positive Residential Care Integration (PRCI) scale (an adapted Positive Home Integration scale) and Strengths and Difficulties Questionnaire—were administered to 511 youth (279 girls and 232 boys), aged 12 to 24 years, across 46 Portuguese residential care institutions. The study examined the face validity, discriminant validity, and reliability of the PRCI scale. Confirmatory factor analysis indicated good model fit, supporting a unidimensional six-item structure. Correlation analyses demonstrated associations with psychological adjustment and sociodemographic variables. The PRCI scale showed satisfactory psychometric properties, confirming its reliability for assessing youth integration in residential care. Cross-gender measurement invariance was also confirmed. These findings underscore the instrument’s relevance and validity for evaluating integration within residential settings and provide valuable guidance for caregivers, professionals, and caseworkers in child welfare services.
- Positive residential care integration scale: Portuguese adaptation and validationPublication . Simão, Ana; Martins, Cátia; Ratinho, Elias; Kothari, Brianne H.; Nunes, CristinaYoung people in residential care settings hold distinct preferences regarding their relationships with key adults, including caseworkers and caregivers. However, their perspectives are not consistently assessed or effectively integrated into case planning. Evaluating this integration is essential for fostering positive adjustment and placement stability. Given that residential care represents the predominant child welfare intervention in Portugal, this study adapts and validates an existing instrument for use with youth in residential care institutions, providing evidence of its validity and reliability. Self-report questionnaires-the Positive Residential Care Integration (PRCI) scale (an adapted Positive Home Integration scale) and Strengths and Difficulties Questionnaire-were administered to 511 youth (279 girls and 232 boys), aged 12 to 24 years, across 46 Portuguese residential care institutions. The study examined the face validity, discriminant validity, and reliability of the PRCI scale. Confirmatory factor analysis indicated good model fit, supporting a unidimensional six-item structure. Correlation analyses demonstrated associations with psychological adjustment and sociodemographic variables. The PRCI scale showed satisfactory psychometric properties, confirming its reliability for assessing youth integration in residential care. Cross-gender measurement invariance was also confirmed. These findings underscore the instrument's relevance and validity for evaluating integration within residential settings and provide valuable guidance for caregivers, professionals, and caseworkers in child welfare services.
- Assessing the bioactive potential of Lysimachia atropurpurea extracts using HPLC-MS/MS, in vitro and in silico analysisPublication . Ak, Gunes; Nilofar, Nilofar; Saka, Enver; Uba, Abdullahi Ibrahim; Rodrigues, Maria João; Fernandes, Eliana; Custódio, Luísa; Yildiztugay, Evren; Yapıcı, Ismail; Gulcin, Ilhami; Mahmoud, Orchid A.; Eldahshan, Omayma A.; Singab, Abdel Nasser B.; Wu, Yimao; Li, Meng-Yao; Zengin, GokhanThe genus Lysimachia is of great interest to the scientific community, especially in terms of its potential anticancer effects. In this study, the aerial parts and roots of Lysimachia atropurpurea L. were collected and extracted by maceration using solvents of ethyl acetate (EA), ethanol (EtOH), ethanol/water, and water. The biological activities of the extracts, including antioxidant, enzyme inhibition, and anticancer effects, were evaluated using various assays. High-performance liquid chromatographytandem mass spectrometry (HPLC-MS/MS) analysis revealed a total of 32 compounds in the extracts of L. atropurpurea. The roots showed significantly the highest antioxidant activity compared to the aerial part. In case of cholinesterase inhibition, the aerial parts of the EtOH extract showed the highest acetylcholinesterase (AChE) inhibition activity, measuring 3.05 mg galatamine equivalent (GALAE)/g. The EtOH and EtOH/water extracts exhibited the strongest cytotoxicity, reducing the viability of human neuroblastoma (SH-SY5Y) and human hepatocarcinoma (HepG2) cancer cells to as low as 4.86–6.33 %. The results of network pharmacology and molecular docking suggest that the extract of L. atropurpurea exerts inhibitory effects on hepatocellular carcinoma through the modulation of SRC, PI3K, and HSP90, while it demonstrates potential inhibitory activity against neuroblastoma by targeting SRC, PI3K, HSP90, ESR1, AKT, and other related targets. In conclusion, the L. atropurpurea extracts showed potential antioxidant, enzyme inhibition, and selective anticancer effects, which support their potential for further research as therapeutic agents in drug development.