Percorrer por data de Publicação, começado por "2026-01-19"
A mostrar 1 - 3 de 3
Resultados por página
Opções de ordenação
- Neuroimaging and pathology biomarkers in parkinson’s disease and parkinsonismPublication . Cilia, Roberto; Arnaldi, Dario; Ballanger, Bénédicte; Ceravolo, Roberto; Micco, Rosa De; Del Sole, Angelo; Eleopra, Roberto; Endo, Hironobu; Fasano, Alfonso; Hoenig, Merle C.; Horsager, Jacob; Lehéricy, Stéphane; Leta, Valentina; Moda, Fabio; Nolano, Maria; Outeiro, Tiago; Parkkinen, Laura; Pavese, Nicola; Quattrone, Andrea; Ray, Nicola J.; Reich, Martin M.; Rektorová, Irena; Strafella, Antonio P.; Tagliavini, Fabrizio; Tessitore, Alessandro; van Eimeren, ThiloThe “Neuroimaging and Pathology Biomarkers in Parkinson’s Disease” course held on 12–13 September 2025 in Milan, Italy, convened an international faculty to review state-ofthe- art biomarkers spanning neurotransmitter dysfunction, protein pathology and clinical translation. Here, we synthesize the four themed sessions and highlights convergent messages for diagnosis, stratification and trial design. The first session focused on neuroimaging markers of neurotransmitter dysfunction, highlighting how positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) provided complementary insights into dopaminergic, noradrenergic, cholinergic and serotonergic dysfunction. The second session addressed in vivo imaging of protein pathology, presenting recent advances in PET ligands targeting α- synuclein, progress in four-repeat tau imaging for progressive supranuclear palsy and corticobasal syndromes, and the prognostic relevance of amyloid imaging in the context of mixed pathologies. Imaging of neuroinflammation captures inflammatory processes in vivo and helps study pathophysiological effects. The third session bridged pathology and disease mechanisms, covering the biology of α-synuclein and emerging therapeutic strategies, the clinical potential of seed amplification assays and skin biopsy, the impact of co-pathologies on disease expression, and the “brain-first” versus “body-first” model of pathological spread. Finally, the fourth session addressed disease progression and clinical translation, focusing on imaging predictors of phenoconversion from prodromal to clinically overt stages of synucleinopathies, concepts of neural reserve and compensation, imaging correlates of cognitive impairment, and MRI approaches for atypical parkinsonism. Biomarker-informed pharmacological, infusion-based, and surgical strategies, including network-guided and adaptive deep brain stimulation, were discussed as examples of how multimodal biomarkers may inform personalized management. Across all sessions, the need for harmonization, longitudinal validation, and pathology-confirmed outcome measures was consistently emphasized as essential for advancing biomarker qualification in multicentre research and clinical practice.
- Trophic group responses to marine reserve protection in temperate and tropical reefs: a systematic review and meta-analysisPublication . Cardoso-Andrade, Mariana; Horta e Costa, Barbara; Hall, Andreia; Gonçalves, Jorge Manuel Santos; Queiroga, HenriqueMarine reserves impact not only exploited species but also other groups, highlighting broader ecological effects within marine communities. While some of these effects are well documented, comprehensive assessments of overall reserve impacts on functional guilds and community structure remain limited. Our systematic review and meta-analyses used structural metrics to test global patterns across 138 tropical and temperate reef reserves, covering seven fish and invertebrate trophic groups and 11 macroalgae and coral morphological groups (99 studies, 679 response-ratio values). In tropical reserves, herbivorous fish presented the highest positive response, followed by carnivores. Potential indirect negative effects may result from predatory fish reducing herbivorous invertebrates and herbivorous fish decreasing macroalgae. Coral cover was higher inside reserves, while algal cover declined. In temperate reserves, herbivorous invertebrate declines did not appear to consistently affect macroalgae, indicating context-dependent outcomes. These results suggest both direct and indirect effects of protection, contributing to valuable insights for ecosystem-based management.
- 30th journal of management and organization birthday: valuable advice for management researchersPublication . Ratten, Vanessa; Hibbert, Paul; Ng, Eddy; Almeida, Shamika; Jayaweerage, Niluka; Scaringella, Laurent; Nguyen, Huong; Presbitero, Alfred; Kumar, Rajkhush; Ferrigno, Giulio; Pinto, Hugo; Guan, BichenAs part of the Journal of Management and Organization’s 30th birthday celebration it is important to reflect and consider what is valuable advice. This perspective article is coauthored by a number of academics and brings together their thoughts about value in management practice. An international array of management teachers and researchers provide their advice in the hope of inspiring future generations of management researchers.