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- Advanced nanotherapeutic strategies transforming diabetic wound healingPublication . Ramos, Filipa; Kumar, Girish; Virmani, Tarun; Sharma, Abhishek; Duarte, Sofia O. D.; Fonte, PedroDue to their high recurrence rates and slow healing, diabetic wounds are becoming a greater public health concern [Citation1]. Each year, 1.6 million cases of diabetic wounds occur in the United States alone, affecting approximately 18.6 million people worldwide [Citation2]. Because of poor cellular regeneration, increased inflammation, and reduced angiogenesis, traditional treatments like debridement, antibiotics, and dressings usually do not work [Citation3]. To overcome the limitations of traditional treatments, there is now a significant demand for advanced therapeutic modalities that promise accurate, efficient, and rapid healing processes [Citation4]. These include microneedles (MNs), exosomes, tetrahedral framework nucleic acids (tFNAs), three-dimensional scaffolds, gene therapy, oxygen-releasing biomaterials, phototherapies, and nanozymes.
- Gravitational waves from two scalar fields unifying the dark sector with inflationPublication . Luongo, Orlando; Mengoni, Tommaso; Sá, PauloWe investigate the gravitational-wave background predicted by a two-scalar-field cosmological model that aims to unify primordial inflation with the dark sector, namely late-time dark energy and dark matter, in a single and self-consistent theoretical framework. The model is constructed from an action inspired by several extensions of general relativity and string-inspired scenarios and features a non-minimal interaction between the two scalar fields, while both remain minimally coupled to gravity. In this context, we derive the gravitational-wave energy spectrum over wavelengths ranging from today’s Hubble horizon to those at the end of inflation. We employ the continuous Bogoliubov coefficient formalism, originally introduced to describe particle creation in an expanding Universe, in analogy to the well-established mechanism of gravitational particle production and, in particular, generalized to gravitons. Using this method, which enables an accurate description of graviton creation across all cosmological epochs, we find that inflation provides the dominant gravitational-wave contribution, while subdominant features arise at the inflation-radiation, radiation-matter, and matter-dark energy transitions, i.e., epochs naturally encoded inside our scalar field picture. The resulting energy density spectrum is thus compared with the sensitivity curves of the planned nextgeneration ground- and space-based gravitational-wave observatories. The comparison identifies frequency bands where the predicted signal could be probed, providing those windows associated with potentially detectable signals, bounded by our analyses. Consequences of our recipe are thus compared with numerical outcomes and the corresponding physical properties discussed in detail.
- Phantom cosmology with arbitrary potential: New accelerating scaling attractorsPublication . Halde, Sudip; Pan, Supriya; Sá, Paulo; Saha, TapanIn this article, we investigate the existence of accelerating scaling solutions in coupled phantom cosmology without assuming any specific potential for the phantom scalar field. The coupling between phantom dark energy and dark matter is motivated by the warm inflationary paradigm, with the dissipation coefficient assumed to be either constant or variable. The evolution equations are written in the form of autonomous systems, whose stability is studied using methods of qualitative analysis of dynamical systems. For this analysis, the only requirement imposed on the otherwise arbitrary phantom potential is that a particular dynamical variable, defined in terms of the potential and its derivative, must be invertible. For such a generic potential, we show that accelerated scaling solutions do exist, for both constant and variable dissipation coefficients. Although there is a limitation to these scaling solutions – specifically, the current stage of accelerated expansion is not preceded by a long enough matter-dominated era – our results show that the existence of a direct coupling between phantom dark energy and dark matter yields great potential for addressing the cosmic coincidence problem.