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  • Dietary 1.3-1.6 yeast β-glucans enhance immune response and disease resilience in European seabass challenged with Tenacibaculum maritimum
    Publication . Orelhas Cabano, Miguel; Richard, Nadège; Schulthess, Julie; Pinto, Lourenço Ramos; Cunha, Francisco Pinto; Peixoto, Maria João; Aragão, Cláudia; Costas, Benjamin
    Introduction: Nutritional strategies have emerged as promising tools to modulate immune responses in marine fish, particularly at mucosal surfaces involved in host-pathogen interactions. Dietary immunomodulators such as yeast-derived bglucans (BG) have gained attention for their capacity to enhance innate immune defenses, however their role in coordinating these mechanisms during bacterial infections remains incompletely understood. Methods: This study evaluated the effects of two dietary inclusion levels (0.06 and 0.12%) of purified yeast b-1,3/1,6-glucans on the immune responses of European seabass (Dicentrarchus labrax) following a bath challenge with Tenacibaculum maritimum specifically. After four weeks of feeding with experimental diets, fish were exposed to a sub-lethal infection, and immune parameters were accessed in the skin, intestinal mucosa and at systemic level. Results: Growth performance and feed efficiency were not affected by BG supplementation. At 24 h post-infection, fish fed with the 0.12% BG diet maintained circulating leukocyte counts and displayed increased plasma lysozyme activity, indicating enhanced early immune readiness. Moreover skin immune responses showed an early upregulation of pro-inflammatory and antimicrobial related genes, followed by increased expression of regulatory cytokines at 7 days post-infection, suggesting an efficient transition from immune activation to resolution. In contrast, intestinal immune responses remained largely unchanged, indicating a compartmentalized modulation focused on the primary site of infection. Conclusion: Overall, dietary BG supplementation exerted a dose dependent immunostimulatory effect in European seabass, with 0.12% BG eliciting the most significant chances in disease resilience
    2026-04-20Artigo científico Acesso aberto Ver mais
  • Structural features of highly bioactive citrus integroPectin revealed by x‐ray diffraction, fourier transform infrared, and nanoparticle tracking analysis
    Publication . Ciriminna, Rosaria; Angellotti, Giuseppe; Petri, Giovanna Li; Valenza, Chiara; Mauriello, Francesco; Nuzzo, Domenico; Picone, Pasquale; Girgenti, Antonella; Sano, Caterina Di; D’Anna, Claudia; Pagliaro, Mario; Garcia, Ana
    Citrus IntegroPectin denotes a family of flavonoid-pectin bioconjugates with large therapeutic potential sourced via the green extraction CytroCav process consisting of cavitation of industrial citrus processing waste conducted in water only, followed by dialysis and lyophilization or spray-drying. We investigate the structure of lemon, orange, and red (blood) orange IntegroPectin using X-ray diffraction, infrared spectroscopy, and nanoparticle tracking analysis. The analysis unveils several structural nuances unique to this new class of bioconjugates of relevance to forthcoming studies on the use of citrus IntegroPectin for therapy and prevention of numerous diseases.
    2026-04-20Artigo científico Acesso aberto Ver mais