Percorrer por data de Publicação, começado por "2026-07-14"
A mostrar 1 - 2 de 2
Resultados por página
Opções de ordenação
- Assessment of cell disruption methods in an integrated multi-product biorefinery for Nannochloropsis Oceanica: from process design to economic analysis.Publication . Cunha, Pedro; Carvalho, Bernardo; Kholany, Mariam; Pereira, Hugo; Varela, JoãoMicroalgae are bioresources with significant potential within a sustainable, circular, bio-economy. However, high production costs have limited the widespread use of algae biomass. This study aimed to develop a multi-product biorefinery for Nannochloropsis oceanica that generates multiple revenue streams from the biomass, thereby enhancing the economic viability of algal production. The effectiveness of cell wall disruption using high-pressure homogenization and enzymatic hydrolysis was evaluated. Enzymatic hydrolysis solubilized nearly half (48.2 ± 1.5%) of the dry cell weight, compared to only 27.3 ± 3.2% with high-pressure homogenization, resulting in more concentrated water-soluble fractions and significantly higher protein extraction yields. Lipid extracts obtained after enzymatic hydrolysis had higher lipid (72.0 ± 5.3% w/w) and eicosapentaenoic acid (28.1 ± 6.9% w/w) contents than those from high-pressure homogenization (38.8 ± 6.1% w/w lipids; 9.1 ± 0.6% w/w eicosapentaenoic acid), despite similar lipid extraction yields (around 30%). Increasing the ethanol volumetric ratio from 58% to 75% v/v significantly improved lipid extraction yields (57.4 ± 3.1%) in the enzymatic hydrolysis-based biorefinery, with even higher yields observed upon scaling up (70.1%). All fractions, including lipid extracts, exhibited a balanced essential amino acid profile that exceeded the WHO/FAO/UNU-recommended values. A preliminary economic analysis indicated that lipid production was more cost-effective when cells were permeabilized by enzymatic hydrolysis than by high-pressure homogenization.
- Special Issue: toxicity of metals, metal-based drugs, and microplasticsPublication . Ścibior, Agnieszka; Aureliano, Manuel; Llopis, JuanIn the present Special Issue (SI), titled “Toxicity of Metals, Metal-Based Drugs, and Microplastics”, an attempt has been made to include reports updating our knowledge about micro- and nanoplastics, certain airborne metals, some metals/metal complexes, chemotherapeutic drugs, and antioxidants. More precisely, this SI provides a review on the development of fluorescent probes essential for monitoring the presence of microand nanoplastics in the environment, examines micro- and nanoplastics as endocrinedisrupting factors, addresses the sources, toxicokinetics, and toxicodynamics of the most relevant metals associated with air pollution and their effects on vulnerable populations, describes some trace metals as essential nutrients and environmental toxicants, discusses the therapeutic potential of metal-based and PARP inhibitor chemotherapy for BRCA1- associated triple-negative breast cancer, and collects data on the influence of cisplatin on the functionality and surface characteristics of mesenchymal stromal cells. In addition, this SI provides valuable findings on the importance of some natural antioxidants like Coenzyme Q10 in addressing the neurotoxic impacts of chemotherapy. The scientific articles making up this SI, i.e., five review articles and two original papers (seven in total), have garnered a total of 44 citations and 23,143 views, indicating an average of 6 citations and 3306 views per publication (26 June 2026). Figure 1 summarizes the issues included in this SI.