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- Unraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer's and Parkinson's diseases.Publication . Simao, Sonia; Filipa Santos, Daniela; Teixeira, Mariana; Ribeiro Agostinho, Rafaela; Rodrigues, Joana; Vitorino, Marta; Pombinho de Araújo, Inês MariaAlzheimer's disease and Parkinson's disease are the two most prevalent neurodegenerative disorders worldwide, both characterized by progressive neuronal loss. Despite distinct pathophysiological features, they share cellular dysfunctions such as abnormal protein aggregation, oxidative stress, and neuroinflammation, research into which might be beneficial for developing novel therapeutic strategies that could tackle both conditions. This review highlights the emerging role of the gasotransmitters nitric oxide, carbon monoxide and hydrogen sulfide as modulators of adult neurogenesis and neuroprotection in Alzheimer's disease and Parkinson's disease. We have gathered recent evidence demonstrating that these endogenous gases exert anti-inflammatory, antioxidant, and anti-apoptotic effects, and, critically, promote neurogenesis - suggesting a dual neuroprotective and neuroregenerative therapeutic potential. The unique physicochemical features of these gasotransmitters, including their ability to cross the blood-brain barrier and diffuse rapidly throughout the neural tissue, further support their suitability as candidates for innovative neuroregenerative treatments. While clinical translation remains challenging, harnessing the neurogenic and neuroprotective actions of these gasotransmitters may offer transformative avenues for addressing the increasing burden of Alzheimer's disease and Parkinson's disease.
- Towards inclusive digital traceability in fisheries: Expert perspectives and the European Union regulatory frameworkPublication . Costa, Gisela; Pita, Cristina; Rangel, MafaldaWith the globalization of aquatic food markets and rising legislative demands, traceability systems are gaining traction both as tools for tracking products, as well as potential levers for improving management, equity, and social responsibility across supply chains. However, their current implementation in fisheries often reinforces existing power imbalances, raises concerns about unequal burdens on supply chain actors, exposes interoperability challenges and the existent restricted information flows to consumers. To better understand digital traceability dynamics in fisheries, experts from a range of sectors (including the fishing industry, research and technology) were interviewed (n = 43) to identify key incentives and barriers about these systems. The study proposes a conceptual framework linking influencing factors (drivers, challenges, and solutions) to key dimensions of digital traceability systems, including governance, costs, data ownership, and technology use. Findings reveal that economic factors dominate both as primary drivers and as barriers to adoption of digital traceability. While stakeholders recognize benefits such as improved market access or enhanced consumer trust, they also highlight implementation and maintenance costs as continuous major challenges, particularly for small-scale fisheries and businesses. Experts also emphasize the importance of developing context-specific and interoperable solutions, supported by adequate financial and technical assistance. Additionally, regulation can be a powerful catalyst for the adoption of digital traceability in fisheries, but to be effective, it must go beyond just aiming for legal compliance to also foster inclusivity, resilience, and shared responsibility across fisheries value chains.
- Chlorella vulgaris-enriched plant-based meat analogue: nutritional, vitamin B12 and techno-functional propertiesPublication . Khemiri, Sheyma; Ferreira, Sara; Pereira, Hugo; Raymundo, AnabelaMicroalgae have emerged as promising alternative protein sources owing to their high nutritional value and abundance of essential micronutrients. In this study, Chlorella vulgaris biomasses produced under varied cultivation conditions were incorporated into plant-based meat (PBM) formulations through the partial replacement of egg white powder, starch, and psyllium. The aim was to evaluate the effects of Chlorella incorporation on the nutritional, digestive, and techno-functional properties of the resulting formulations. Chlorella significantly increased protein, mineral, and vitamin B12 contents. All biomasses and PBM formulations contained substantial amounts of methylcobalamin and cyanocobalamin, with HPLC-DAD analysis identifying methylcobalamin as the predominant cobalamin form. In vitro digestion demonstrated improved protein and dry matter digestibility, particularly in heterotrophically–cultivated Chlorella formulations. Rheological and textural analyses showed that microalgal incorporation increased firmness and viscoelastic behavior, whereas cohesiveness remained unaffected. The differences observed among formulations reflected the compositional characteristics of the respective Chlorella biomasses. Overall, these findings demonstrate the potential of Chlorella vulgaris biomass as a multifunctional ingredient for improving the nutritional quality and techno-functional properties of plant-based meat analogues..
- Environmental responsibility as a value proposition: Segmenting coastal tourists through perceived destination environmental responsibilityPublication . de Castro Rezende, Aline; Martins Guerreiro, Maria Manuela; Nobre Pereira, LuisEnvironmental responsibility is increasingly recognized as a key contributor to destination competitiveness, particularly in coastal tourism contexts where environmental quality is closely linked to visitor experiences. However, limited research has examined how tourists perceive environmental responsibility and how these perceptions can be used for market segmentation. Addressing this gap, this study conceptualizes Destination Environmental Responsibility (DER) as a perception-based construct and operationalizes it as a segmentation criterion. Using survey data from 1909 tourists in the Algarve (Portugal), cluster analysis identified three distinct segments: eco-engaged, eco-friendly, and eco-restrained. The results indicate that tourists generally evaluate environmental responsibility positively, particularly for cleanliness and environmental preservation. Importantly, DER provides a meaningful basis for segmentation, revealing differences in tourism profiles, satisfaction, and loyalty. Tourists with stronger environmental evaluations report higher levels of satisfaction and loyalty, suggesting that perceived environmental responsibility is associated with destination differentiation and competitiveness, as well as more positive tourism experiences and behavioral intentions. The study contributes to the literature by advancing DER as a perception-based, formative construct, extending segmentation research by positioning perceived environmental responsibility as a segmentation criterion, and demonstrating how tourists’environ mental evaluations can inform destination positioning. Heterogeneity in these evaluations is interpreted through the complementary perspectives of VBN, S–O–R, and TPB. From a managerial perspective, the findings emphasize the importance of visible, segment-specific sustain ability strategies. By aligning environmental practices with different tourist profiles, destination management organizations may strengthen visitor satisfaction, loyalty, and competitive positioning in coastal tourism markets.