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Percorrer UAlg-Teses por Objetivos de Desenvolvimento Sustentável (ODS) "ODS 3 — Saúde de Qualidade"
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- From data to discovery: designing new pipelines for the analysis of high-throughput antibody data in Malaria and Chronic Fatigue SyndromePublication . Fonseca, André Filipe Afonso de Sousa; Sepúlveda, Nuno; Cordeiro, ClaraCurrent serological studies, where thousands of antibodies can now be simultaneously screened, has allowed to enhance our understanding of the immune responses to various pathogens and to support the development of better diagnostic tools and treatment strategies. Nonetheless, the complexity of such data has broughtnewhurdles regarding the capability of traditional statistical methods to cope with such data. Although Machine Learning (ML) techniques have offered enhanced capabilities to unravel antibody biomarkers, the exact identity of antibody biomarkers against certain diseases remains a struggle. This challenge underscores the pressing need for innovative methodologies to enhance the accuracy in biomarker identification, facilitatingmore effective diagnostics and targeted therapeutics. In this thesis I developed analytical pipelines for the analysis of high-throughput antibody data. To illustrate the potential of these pipelines, I focused on antibody data on Malaria and Chronic Fatigue Syndrome/MyalgicEncephalomyelitis. Ingeneral, these pipelines were based on an initial variable selection step to identify the most relevant and informative variables, followed by a predictive step where distinct classifiers would be constructed using ML-based approaches. At first, distinct approaches for the analysis of a relative low number of antibodies under analysis to test the suitability on the analysis of such data. We then proceeded to analyze data containing thousands of antibodies. This morechallenging situation motivatedmeto fine-tune the initial pipelines to better cope with the high dimensionality of the data. Each pipeline leveraged different statistical assumptions and yielded benefits and drawbacks, providing predictive accuracies that ranged fromclose to 72% up to 90% when implemented on different datasets, surpassing previous published analyzes on he same data. In conclusion, these new pipelines generated a good predictive performance in the case studies evaluated. Given that they are based on general principles of data analysis, they have the potential to increase the robustness and reproducibility of the analysis of highdimensional antibody data.
- A importância das emoções em idade pré-escolar: crescer a aprenderPublication . Carrasco, Tânia Isabel Branquinho; Luísa, Cláudia Cristina GuerreiroO presente relatório intitulado: “A Importância das Emoções em idade Pré-Escolar: Crescer a Aprender” foi desenvolvido no âmbito da unidade curricular de Prática de Ensino Supervisionada, inserida no 2º ano do curso de Mestrado em Educação Pré-Escolar. Este estudo contou com um total de vinte e cinco crianças com idades compreendidas entre os três e os seis anos, sendo que a instituição se encontra localizada na cidade de Albufeira. Como principais objetivos a investigação visou promover o desenvolvimento emocional nas crianças e proporcionar a sua regulação em idade pré-escolar. Foi definida uma questão de partida para estudo, a qual incidiu sobre: “Qual a importância do desenvolvimento emocional em idade pré-escolar? A investigação em questão, é de carácter qualitativo com o intuito de analisar os comportamentos e atitudes, compreender e combater os problemas. Neste estudo foi necessário utilizar diversas técnicas de recolha de dados: análise documental, pesquisa bibliográfica, notas de campo, registos audiovisuais e entrevistas semiestruturadas. A importância das emoções na educação pré-escolar é um tema importante a ser trabalhado nesta idade, pois, é aqui que a criança aprende diferentes formas de se relacionar com os outros e de se expressar, sendo importante prepará-las desde cedo para viver em sociedade. No final do estudo foi possível verificar um progresso nas crianças, pois, já falavam abertamente, conseguiam exprimir e explicar o que sentiam, reconhecendo em si e nos pares/colegas as emoções.
- The role of creative tourism in tackling social exclusion among older artisans: The case of Loulé CriativoPublication . Akdemir, Hilal; Gonçalves, Maria Alexandra Patrocínio Rodrigues; José, José Manuel Sousa de SãoThis thesis investigates the transformative potential of creative tourism by examining its role in tackling social exclusion among older artisans and enhancing their quality of life. Structured as three interconnected papers, the research includes a systematic review of the literature, and two qualitative papers reporting an exploratory case study within the Loulé Criativo Turismo Network. The first paper presents a comprehensive map of empirical research on creative tourism, revealing lines of research, research settings and participants, theoretical approaches, research conclusions, and methodological imbalances. The second paper explores the role of creative tourism in tackling social exclusion among older artisans, emphasizing which and how the various dimensions of social exclusion are positively affected by the provision of creative tourism activities by older artisans. The third paper examines the impact of creative tourism on the quality of life of older artisans, identifying the dimensions of quality of life that are positively impacted by the participation of older artisans in the provision of creative tourism activities, as well as the mechanisms through which this impact occurs. The results of these two papers clearly point to the role of creative tourism in promoting social inclusion and quality of life for older artisans. These results have implications for tourism research, as well as to policy and professional practice. All in all, this thesis establishes a link between creative tourism, social inclusion, and quality of life, emphasizing the need for heightened awareness among researchers, tourism professionals and policymakers to harness the full potential of creative tourism in contributing to the well-being of individuals involved in or affected by creative tourism activities.