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Catamo Vaz, Deise Haua da Silva

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  • Possible role of mycotoxins, malnutrition and MECP2 dysregulation in nodding syndrome
    Publication . Catamo Vaz, Deise Haua da Silva; Costa, Maria Helena da; Buque, Helena Agostinho; Nzwalo, Hipólito
    We read with great interest the manuscript by Spencer et al. [1] suggesting a possible role of Methyl-CpG-binding protein 2 (MECP2) dysregulation in the pathogenesis of Nodding syndrome (NS), a childhood onset epileptic disorder occurring exclusively in sub-Saharan Africa. The sociodemographic and phenotypic overlap of NS with MECP2 duplication syndrome, namely the age of onset interval, female predominance;