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- Cystoseira algae (Fucaceae): update on their chemical entities and biological activitiesPublication . Bruno De Sousa, Carolina; Gangadhar N. Katkam, Dr.; Macridachis, Jorge; Pavao, Madalena; Morais, Thiago R.; Campino, Lenea; J. C. or Varela J. or Varela J.C.S., Varela; Lago, Joao Henrique G.Cystoseira (Sargassaceae) is a genus of marine brown algae composed of about 40 species, which is distributed along the Eastern Atlantic and Mediterranean coasts. The biological potential of the Cystoseira genus has been investigated and several activities have been reported. Chemically, this genus contains a wide variety of secondary metabolites, such as terpenoids, steroids, phlorotannins and phenolic compounds. Additionally, other chemical components as, for instance, carbohydrates, triacylglycerolsgatty acids, pigments as well as vitamins have been identified in the studied species. Some of the isolated compounds were associated with the reported pharmacological properties, as for example antioxidant, anti-inflammatory, cytotoxicity, anticancer, cholinesterase inhibition, anti-diabetic, activities but also antibacterial, antifungal and anti-parasitic activities. In this review, we provide a comprehensive overview of the compounds isolated and identified after 1995 from the different species of Cystoseira, compiling more than 200 compounds isolated, together with their therapeutic potential. (C) 2017 Elsevier Ltd. All rights reserved.
- Report of in vitro antileishmanial properties of Iberian macroalgaePublication . Bruno De Sousa, Carolina; Lago, Joao Henrique G.; Macridachis, Jorge; Oliveira, Marta; Fonseca Brito, Luis; Vizetto-Duarte, Catarina; Florindo, Claudia; Hendrickx, Sarah; Maes, Louis; Morais, Thiago; Uemi, Miriam; Neto, Luis; Dionísio, Lídia; Cortes, Sofia; Barreira, Luísa; Custódio, Luísa; Albericio, Fernando; Campino, Lenea; Varela, J.Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8-101.8 mu g/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 mu g/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives. [GRAPHICS] .
- Report of in vitro antileishmanial properties of Iberian macroalgaePublication . Bruno De Sousa, Carolina; Lago, João Henrique G.; Macridachis, Jorge; Oliveira, Marta; Brito, Luis; Vizetto-Duarte, C; Florindo, Claudia; Hendrickx, Sarah; Maes, Louis; Morais, Thiago; Uemi, Miriam; Neto, Luís; Dionísio, Lídia; Cortes, Sofia; Barreira, Luísa; Custódio, Luísa; Alberício, Fernando; Campino, Lenea; Varela, JoãoHere is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8-101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.