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- Vanadium compounds therapeutic effects in melanomaPublication . Amante, Cristina I.; Aureliano, Manuel; De Sousa-Coelho, Ana LuísaPolyoxometalates are a diverse family of metal-oxo anions of early transitional metal ions in high oxidation states, including vanadium. Such compounds are gaining increasing interest in biomedicine due to their anti-cancer activity. Regarding melanoma, available therapies’ effectiveness is still currently limited, commonly leading to relapse. For this reason, it is vital to identify novel anti-cancer agents.