NOVEL APPROACH TO PORPHYRIN DERIVATIVES WITH HIGH WAVELENGTH ABSORPTION FOR PHOTODYNAMIC THERAPY AND DIAGNOSIS OF CANCER

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On-water synthesis of dipyrromethanes via bis-hetero-diels–alder reaction of Azo- and Nitrosoalkenes with Pyrrole

Publication . Pinho e Melo, Teresa; Lemos, Americo; Pereira, Nelson; Lopes, Susana

An unprecedented one-pot approach to 5-substituted dipyrromethanes based on the hetero-Diels-Alder reaction of azo- and nitrosoalkenes is described. The on-water reaction conditions led to the target compounds in higher yields with significantly shorter reaction times and simpler purification procedures than carrying out the reaction in dichloromethane or in the absence of solvent.

2013Journal article

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