Exploitation of aromatic plants’ by-products for the development of  novel cosmeceuticals and food supplements.

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Chemical composition, antibacterial screening and cytotoxic activity of Chiliadenus antiatlanticus (Asteraceae) essential oil

Publication . El Yaagoubi, Mohamed; Ortiz, Sergio; Mechqoq, Hicham; Cavaleiro, Carlos; Lecso-Bornet, Marylin; Rodrigues, Maria Joao; Custódio, Luísa; El Mousadik, Abdelhamid; Grougnet, Raphael; El Aouad, Noureddine; Msanda, Fouad; Kritsanida, Marina

The chemical composition and in vitro antibacterial and cytotoxic activities of the essential oil (EO) of Chiliadenus antiatlanticus (Emb. & Maire) Gomiz, an asteraceous species endemic to the southwest of Morocco, were investigated. The EO yield was 1.07 +/- 0.28 %, twenty-seven metabolites were identified representing more than 96.4 % of the total composition. Camphor (35.7 %) and derivatives, borneol (4.9 %) and camphene (4.2 %) together with intermedeol (19.9 %), alpha-pinene (15.5 %) and (E)-pinocarveol (4.1 %) were the major constituents. An antibacterial activity was noticed against 24 strains (all Gram-positive) out of 71 at MICs values=100 mu g/mL. The EO also showed significant toxicity towards liver HepG2 (55.8 % of cell viability) and melanoma B16 4A5 (41.6 % of cell viability) tumor cell lines at 100 mu g/mL.

2021-06Journal article

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Chemical composition and biological screening of the essential oils of Micromeria macrosiphon and M. arganietorum (Lamiaceae)

Publication . El Yaagoubi, Mohamed; Mechqoq, Hicham; Ortiz, Sergio; Cavaleiro, Carlos; Lecsö‐Bornet, Marylin; Pereira, Catarina; Rodrigues, Maria Joao; Custódio, Luísa; El Mousadik, Abdelhamid; Picot, Laurent; Kritsanida, Marina; Msanda, Fouad; El Aouad, Noureddine; Grougnet, Raphaël

The chemical composition and in vitro biological activities of the essential oil (EO) of Micromeria macrosiphon Coss. and M. arganietorum (J. Emb.) R. Morales, two Lamiaceae endemic to south Morocco, were investigated. GC/MS analysis resulted in the identification of 36 metabolites from the EO of M. macrosiphon, 45 from M. arganietorum. Borneol was the major metabolite in both oils and together with related derivatives such as camphor, accounted for 2/3 of the EO of M. macrosiphon, 1/3 of those of M. arganietorum. Pinene and terpinene derivatives were also present in high proportions. From a chemotaxonomic point of view, the composition of the examined samples may be related to those of other species endemic to Macaronesia. Both EOs showed significant toxicity towards liver HepG2 and melanoma B16 4A5 tumor cell lines at 100 mu g/mL; however, they were also cytotoxic towards S17 normal cell lines, with a selectivity index <1. No antibacterial activity was noticed against 52 strains at 100 mu g/mL.

2021Journal article

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