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Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

Publication . Parente Carvalho, Catia; Norouzy, Amir; Ribeiro, Vera; Nau, Werner M.; Pischel, Uwe

Cucurbiturils (CB6 and CB7) were shown to inhibit the enzymatically catalyzed restriction of plasmids and linear DNA. This effect can be inverted by supramolecular masking of the macrocycles through competitive complexation with polyamines. These experiments provide supramolecular control of biocatalytic processes.

2015-03Journal article

Open access

Five-Component Self-Assembly of Cucurbituril-Based Hetero-pseudorotaxanes

Publication . Parente Carvalho, Catia; Dominguez, Zoe; Dominguez, Cristina; El-Sheshtawy, Hamdy S.; Da Silva, Jose Paulo; Arteaga, Jesus F.; Pischel, Uwe

[5]Pseudorotaxanes can be obtained by self-sorting using heteroditopic guests and various cucurbituril homologues as hosts. The assembly and chemically induced disassembly of the pseudorotaxanes can be monitored by measuring the fluorescence of the anthracene guest in solution. Mass spectral evidence for the supramolecular assemblies is obtained in the gas phase. The disassembly in the gas phase can be achieved by collision-induced dissociation leading to the corresponding [2]- and [3]pseudorotaxanes.

2017-04Journal article

Open access