Publication . Brito, A. B.; Gavaia, Paulo J.; Cancela, Leonor
Teleost fishes have the exceptional ability to largely regenerate severed appendages
comprising several different tissues. Fin regeneration starts through the formation of
heterogeneous mesenchyma-like cells, named blastema, and located between stump
tissues and the wounded epidermis. This event, denominated epimorphic regeneration,
comprises strict growth control and cell reprogramming leading to faithful restoration
of the lost parts. Matrix Gla Protein (Mgp) and Bone Gla Protein (Bgp, osteocalcin)
are small extracellular matrix Gla proteins, members of the vitamin K-dependent
(VKD) family.
