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Changes in levels of essential elements in suckling rats exposed to zinc and mercury

2008Journal article Restricted
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dc.contributor.authorPeixoto, N. C.
dc.contributor.authorRocha, L. C.
dc.contributor.authorMoraes, D. P.
dc.contributor.authorBebianno, Maria João
dc.contributor.authorDressler, V. L.
dc.contributor.authorFlores, E. M. M.
dc.contributor.authorPereira, M. E.
dc.date.accessioned2020-05-06T10:26:40Z
dc.date.available2020-05-06T10:26:40Z
dc.date.issued2008
dc.description.abstractThe effect of mercury and its interaction with zinc on the content of essential metals in tissues from neonate rats was investigated. Three-day-old Wistar rats were treated with saline or 27 mg kg(-1)d(-1) ZnCl2 (s.c.) for five consecutive days. From the 8th to the 12th day of life, the rats received one daily dose of saline or 5.0 mg kg(-1) HgCl2 (s.c). Twenty-four hours after the last injection liver, kidneys and blood were collected for metal quantification. The HgCl(2) exposure induced alterations on metal levels, such as increase of Fe, Hg and Zn in liver, decrease of Fe and Mg and increase of Cu and Hg contents in kidneys. The Hg exposure also increased Hg levels in the blood. The treatment with ZnCl2, administered previously to HgCl2, partially prevented the increase of Fe in the liver, and not only prevented the decrease of renal Mg but also increased it to levels higher than those found in control group. The Zn-Hg rats also presented higher renal Cu levels, and showed partially lower blood and hepatic Hg levels and higher renal Hg levels. The pre-administration of Zn caused no severe alterations in levels of essential metals (Cu, Fe, Mg and Mn). In short, Zn appears to be an alternative treatment of Hg poisoning in young animals in comparison to chelating drugs since these have low metal selectivity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.chemosphere.2008.04.027pt_PT
dc.identifier.issn0045-6535
dc.identifier.urihttp://hdl.handle.net/10400.1/13842
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectAnimalspt_PT
dc.subjectChloridespt_PT
dc.subjectCopperpt_PT
dc.subjectFemalept_PT
dc.subjectIndicators and reagentspt_PT
dc.subjectIronpt_PT
dc.subjectKidneypt_PT
dc.subjectLiverpt_PT
dc.subjectMagnesiumpt_PT
dc.subjectMalept_PT
dc.subjectManganesept_PT
dc.subjectMercuric chloridept_PT
dc.subjectMercurypt_PT
dc.subjectRatspt_PT
dc.subjectZinc compoundspt_PT
dc.subjectElementspt_PT
dc.subjectSucklingpt_PT
dc.subjectYoung ratspt_PT
dc.subjectZincpt_PT
dc.subjectEssential metalspt_PT
dc.titleChanges in levels of essential elements in suckling rats exposed to zinc and mercurypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1332pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1327pt_PT
oaire.citation.titleChemospherept_PT
oaire.citation.volume72pt_PT
person.familyNameBebianno
person.givenNameMaria
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32

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