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Periderm invasion contributes to the epithelial lining of the teleost pharynx
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The gnathostome pharyngeal cavity functions in food transport and respiration. In amniotes the
mouth and nares are the only channels allowing direct contact between internal and external epithelia.
In teleost fsh, gill slits arise through opening of endodermal pouches and connect the pharynx to
the exterior. Using transgenic zebrafsh lines, cell tracing, live imaging and diferent markers, we
investigated if pharyngeal openings enable epithelial invasion and how this modifes the pharyngeal
epithelium. We conclude that in zebrafsh the pharyngeal endoderm becomes overlain by cells with
a peridermal phenotype. In a wave starting from pouch 2, peridermal cells from the outer skin layer
invade the successive pouches until halfway their depth. Here the peridermal cells connect to a
population of cells inside the pharyngeal cavity that express periderm markers, yet do not invade from
outside. The latter population expands along the midline from anterior to posterior until the esophagusgut boundary. Together, our results show a novel role for the periderm as an internal epithelium
becomes adapted to function as an external surface.
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Nature Publishing Gruop