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Dairying, diseases and the evolution of lactase persistence in Europe

2022Journal article Restricted access
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dc.contributor.authorEvershed, Richard P.
dc.contributor.authorDavey Smith, George
dc.contributor.authorRoffet-Salque, Mélanie
dc.contributor.authorTimpson, Adrian
dc.contributor.authorDiekmann, Yoan
dc.contributor.authorLyon, Matthew S.
dc.contributor.authorCramp, Lucy J. E.
dc.contributor.authorCasanova, Emmanuelle
dc.contributor.authorSmyth, Jessica
dc.contributor.authorWhelton, Helen L.
dc.contributor.authorDunne, Julie
dc.contributor.authorBrychova, Veronika
dc.contributor.authorŠoberl, Lucija
dc.contributor.authorGerbault, Pascale
dc.contributor.authorGillis, Rosalind
dc.contributor.authorHeyd, Volker
dc.contributor.authorJohnson, Emily
dc.contributor.authorKendall, Iain
dc.contributor.authorManning, Katie
dc.contributor.authorMarciniak, Arkadiusz
dc.contributor.authorOutram, Alan K.
dc.contributor.authorVigne, Jean-Denis
dc.contributor.authorShennan, Stephen
dc.contributor.authorBevan, Andrew
dc.contributor.authorColledge, Sue
dc.contributor.authorAllason-Jones, Lyndsay
dc.contributor.authorAmkreutz, Luc
dc.contributor.authorAnders, Alexandra
dc.contributor.authorArbogast, Rose-Marie
dc.contributor.authorBălăşescu, Adrian
dc.contributor.authorBánffy, Eszter
dc.contributor.authorBarclay, Alistair
dc.contributor.authorBehrens, Anja
dc.contributor.authorBogucki, Peter
dc.contributor.authorCarrancho Alonso, Ángel
dc.contributor.authorCarretero, José Miguel
dc.contributor.authorCavanagh, Nigel
dc.contributor.authorClaßen, Erich
dc.contributor.authorCollado Giraldo, Hipolito
dc.contributor.authorConrad, Matthias
dc.contributor.authorCsengeri, Piroska
dc.contributor.authorCzerniak, Lech
dc.contributor.authorDębiec, Maciej
dc.contributor.authorDenaire, Anthony
dc.contributor.authorDomboróczki, László
dc.contributor.authorDonald, Christina
dc.contributor.authorEbert, Julia
dc.contributor.authorEvans, Christopher
dc.contributor.authorFrancés-Negro, Marta
dc.contributor.authorGronenborn, Detlef
dc.contributor.authorHaack, Fabian
dc.contributor.authorHalle, Matthias
dc.contributor.authorHamon, Caroline
dc.contributor.authorHülshoff, Roman
dc.contributor.authorIlett, Michael
dc.contributor.authorIriarte, Eneko
dc.contributor.authorJakucs, János
dc.contributor.authorJeunesse, Christian
dc.contributor.authorJohnson, Melanie
dc.contributor.authorJones, Andy M.
dc.contributor.authorKarul, Necmi
dc.contributor.authorKiosak, Dmytro
dc.contributor.authorKotova, Nadezhda
dc.contributor.authorKrause, Rüdiger
dc.contributor.authorKretschmer, Saskia
dc.contributor.authorKrüger, Marta
dc.contributor.authorLefranc, Philippe
dc.contributor.authorLelong, Olivia
dc.contributor.authorLenneis, Eva
dc.contributor.authorLogvin, Andrey
dc.contributor.authorLüth, Friedrich
dc.contributor.authorMarton, Tibor
dc.contributor.authorMarley, Jane
dc.contributor.authorMortimer, Richard
dc.contributor.authorOosterbeek, Luiz
dc.contributor.authorOross, Krisztián
dc.contributor.authorPavúk, Juraj
dc.contributor.authorPechtl, Joachim
dc.contributor.authorPétrequin, Pierre
dc.contributor.authorPollard, Joshua
dc.contributor.authorPollard, Richard
dc.contributor.authorPowlesland, Dominic
dc.contributor.authorPyzel, Joanna
dc.contributor.authorRaczky, Pál
dc.contributor.authorRichardson, Andrew
dc.contributor.authorRowe, Peter
dc.contributor.authorRowland, Stephen
dc.contributor.authorRowlandson, Ian
dc.contributor.authorSaile, Thomas
dc.contributor.authorSebők, Katalin
dc.contributor.authorSchier, Wolfram
dc.contributor.authorSchmalfuß, Germo
dc.contributor.authorSharapova, Svetlana
dc.contributor.authorSharp, Helen
dc.contributor.authorSheridan, Alison
dc.contributor.authorShevnina, Irina
dc.contributor.authorSobkowiak-Tabaka, Iwona
dc.contributor.authorStadler, Peter
dc.contributor.authorStäuble, Harald
dc.contributor.authorStobbe, Astrid
dc.contributor.authorStojanovski, Darko
dc.contributor.authorTasić, Nenad
dc.contributor.authorvan Wijk, Ivo
dc.contributor.authorVostrovská, Ivana
dc.contributor.authorVuković, Jasna
dc.contributor.authorWolfram, Sabine
dc.contributor.authorZeeb-Lanz, Andrea
dc.contributor.authorThomas, Mark G.
dc.date.accessioned2022-12-07T16:54:34Z
dc.date.available2022-12-07T16:54:34Z
dc.date.issued2022
dc.description.abstractIn European and many African, Middle Eastern and southern Asian populations, lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over the past 10,000 years(1). Although the selection of LP and the consumption of prehistoric milk must be linked, considerable uncertainty remains concerning their spatiotemporal configuration and specific interactions(2,3). Here we provide detailed distributions of milk exploitation across Europe over the past 9,000 years using around 7,000 pottery fat residues from more than 550 archaeological sites. European milk use was widespread from the Neolithic period onwards but varied spatially and temporally in intensity. Notably, LP selection varying with levels of prehistoric milk exploitation is no better at explaining LP allele frequency trajectoriesthan uniform selection since the Neolithic period. In the UK Biobank(4,5) cohort of 500,000 contemporary Europeans, LP genotype was only weakly associated with milk consumption and did not show consistent associations with improved fitness or health indicators. This suggests that other reasons for the beneficial effects of LP should be considered for its rapid frequency increase. We propose that lactase non-persistent individuals consumed milk when it became available but, under conditions of famine and/or increased pathogen exposure, this was disadvantageous, driving LP selection in prehistoric Europe. Comparison of model likelihoods indicates that population fluctuations, settlement density and wild animal exploitation-proxies for these drivers-provide better explanations of LP selection than the extent of milk exploitation. These findings offer new perspectives on prehistoric milk exploitation and LP evolution.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1038/s41586-022-05010-7pt_PT
dc.identifier.issn0028-0836
dc.identifier.urihttp://hdl.handle.net/10400.1/18604
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNaturept_PT
dc.titleDairying, diseases and the evolution of lactase persistence in Europept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage345pt_PT
oaire.citation.issue7922pt_PT
oaire.citation.startPage336pt_PT
oaire.citation.titleNaturept_PT
oaire.citation.volume608pt_PT
person.familyNameGillis
person.givenNameRosalind
person.identifier.ciencia-idE216-E640-EEA5
person.identifier.orcid0000-0002-2370-7311
person.identifier.scopus-author-id55821869700
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication298fa835-67bf-4834-8b3b-30504ff1eefb
relation.isAuthorOfPublication.latestForDiscovery298fa835-67bf-4834-8b3b-30504ff1eefb

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