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Inhibition of SERCA and PMCA Ca2+-ATPase activities by polyoxotungstates

2022-08Journal article Open Access
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dc.contributor.authorAureliano, Manuel
dc.contributor.authorFraqueza, Gil
dc.contributor.authorBerrocal, Maria
dc.contributor.authorCordoba-Granados, Juan J.
dc.contributor.authorGumerova, Nadiia I.
dc.contributor.authorRompel, Annette
dc.contributor.authorGutierrez-Merino, Carlos
dc.contributor.authorMata, Ana M.
dc.date.accessioned2023-01-26T14:19:33Z
dc.date.available2023-01-26T14:19:33Z
dc.date.issued2022-08
dc.description.abstractPlasma membrane calcium ATPases (PMCA) and sarco(endo) reticulum calcium ATPases (SERCA) are key proteins in the maintenance of calcium homeostasis. Herein, we compare for the first time the inhibition of SERCA and PMCA calcium pumps by several polyoxotungstates (POTs), namely by Wells-Dawson phospho-tungstate anions [P2W18O62]6-(intact, {P2W18}), [P2W17O61]10-(monolacunary, {P2W17}), [P2W15O56]12-(trilacunary, {P2W15}), [H2P2W12O48]12-(hexalacunary, {P2W12}), [H3P2W15V3O62]6- (trivanadium-substituted, {P2W15V3}) and by Preyssler-type anion [NaP5W30O110]14-({P5W30}). The speciation in the solu-tions of tested POTs was investigated by 31P and 51V NMR spectroscopy. The tested POTs inhibited SERCA Ca2+- ATPase activity, whereby the Preyssler POT showed the strongest effect, with an IC50 value of 0.37 mu M. For {P2W17} and {P2W15V3} higher IC50 values were determined: 0.72 and 0.95 mu M, respectively. The studied POTs showed to be more potent inhibitors of PMCA Ca2+-ATPase activity, with lower IC50 values for {P2W17}, {P5W30} and {P2W15V3}.pt_PT
dc.description.sponsorshipLA/P/0101/2020
dc.description.sponsorshipP33927
dc.description.sponsorshipBFU2017-85723-P
dc.description.sponsorshipP33089
dc.description.sponsorshipPID2020-115512GB-I00
dc.description.sponsorshipMCIN/AEI/10.13039/501100011033
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jinorgbio.2022.111952pt_PT
dc.identifier.eissn1873-3344
dc.identifier.urihttp://hdl.handle.net/10400.1/18943
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolyoxometalatespt_PT
dc.subjectPolyoxometalate?s stabilitypt_PT
dc.subjectCa2+-ATPasept_PT
dc.subjectATPases inhibitorspt_PT
dc.subjectAnticancer drugspt_PT
dc.subjectDrug discoverypt_PT
dc.titleInhibition of SERCA and PMCA Ca2+-ATPase activities by polyoxotungstatespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.citation.startPage111952pt_PT
oaire.citation.titleJournal of Inorganic Biochemistrypt_PT
oaire.citation.volume236pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAureliano
person.familyNameFraqueza
person.givenNameManuel
person.givenNameGil
person.identifier584146
person.identifier1179689
person.identifier.ciencia-idAA14-3490-DC5E
person.identifier.ciencia-id1317-C7C9-5BDA
person.identifier.orcid0000-0003-4858-3201
person.identifier.orcid0000-0003-2969-9292
person.identifier.ridI-3283-2012
person.identifier.ridA-3552-2013
person.identifier.scopus-author-id6603412860
person.identifier.scopus-author-id54683851800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationbb413661-7edd-4b57-8338-33889cfd05db
relation.isAuthorOfPublication9e7ef53d-b79c-4446-9093-0611980e6ecd
relation.isAuthorOfPublication.latestForDiscovery9e7ef53d-b79c-4446-9093-0611980e6ecd
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