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Repurposing anticancer drugs for the management of COVID-19

dc.contributor.authorEl Bairi, Khalid
dc.contributor.authorTrapani, Dario
dc.contributor.authorPetrillo, Angelica
dc.contributor.authorLe Page, Cécile
dc.contributor.authorZbakh, Hanaa
dc.contributor.authorDaniele, Bruno
dc.contributor.authorBelbaraka, Rhizlane
dc.contributor.authorCurigliano, Giuseppe
dc.contributor.authorAfqir, Said
dc.date.accessioned2021-01-11T18:33:48Z
dc.date.available2021-01-11T18:33:48Z
dc.date.issued2020
dc.description.abstractSince its outbreak in the last December, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has rapidly spread worldwide at a pandemic proportion and thus is regarded as a global public health emergency. The existing therapeutic options for COVID-19 beyond the intensive supportive care are limited, with an undefined or modest efficacy reported so far. Drug repurposing represents an enthusiastic mechanism to use approved drugs outside the scope of their original indication and accelerate the discovery of new therapeutic options. With the emergence of COVID-19, drug repurposing has been largely applied for early clinical testing. In this review, we discuss some repurposed anticancer drugs for the treatment of COVID-19, which are under investigation in clinical trials or proposed for the clinical testing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ejca.2020.09.014pt_PT
dc.identifier.issn0959-8049
dc.identifier.urihttp://hdl.handle.net/10400.1/14948
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntineoplastic agentspt_PT
dc.subjectAntiviral agentspt_PT
dc.subjectCOVID-19pt_PT
dc.subjectHumanspt_PT
dc.subjectPandemicspt_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectDrug repositioningpt_PT
dc.titleRepurposing anticancer drugs for the management of COVID-19pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage61pt_PT
oaire.citation.startPage40pt_PT
oaire.citation.titleEuropean Journal of Cancerpt_PT
oaire.citation.volume141pt_PT
person.familyNameZbakh
person.givenNameHanaa
person.identifier.ciencia-idD517-4B23-3AF5
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication32e11144-130e-4eb1-8771-ae2481d8f399
relation.isAuthorOfPublication.latestForDiscovery32e11144-130e-4eb1-8771-ae2481d8f399

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