CRISPR-based strategies in infectious disease diagnosis and therapy

Binnie, Alexandra; Fernandes, Emanuel; Almeida‑Lousada, Helder; De Mello, Ramon Andrade; Castelo-Branco, Pedro

http://hdl.handle.net/10400.1/14994

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Autores

Binnie, Alexandra

Fernandes, Emanuel

Almeida‑Lousada, Helder

De Mello, Ramon Andrade

Castelo-Branco, Pedro

Resumo(s)

CRISPR gene-editing technology has the potential to transform the diagnosis and treatment of infectious diseases, but most clinicians are unaware of its broad applicability. Derived from an ancient microbial defence system, these so-called "molecular scissors" enable precise gene editing with a low error rate. However, CRISPR systems can also be targeted against pathogenic DNA or RNA sequences. This potential is being combined with innovative delivery systems to develop new therapeutic approaches to infectious diseases.