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Halophyte plants as potential sources of Anticancer agents: a comprehensive review

2022-11-08Journal article Open access
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dc.contributor.authorCustódio, Luísa
dc.contributor.authorGarcia-Caparros, Pedro
dc.contributor.authorPereira, Catarina Guerreiro
dc.contributor.authorCastelo-Branco, Pedro
dc.date.accessioned2022-11-14T10:41:19Z
dc.date.available2022-11-14T10:41:19Z
dc.date.issued2022-11-08
dc.date.updated2022-11-10T14:28:19Z
dc.description.abstractSalt-tolerant plants (halophytes) are widely distributed worldwide in several environments such as coastal salt marshes, sand dunes, and inland deserts. To cope with the harsh conditions that characterize those habitats, which include high salinity and radiation levels, such plants have developed morphological and physiological traits, the latter including the synthesis and accumulation of important secondary metabolites such as alkaloids and polyphenols. While essential in maintaining plant homeostasis, these compounds are highly valued in the medical field for the treatment of several human diseases, including cancer. Cancer is one of the most life-threatening disorders worldwide, which accentuates the need to improve current cancer therapies and minimize potential adverse secondary side-effects. In this context, the pharmacological evaluation of natural compounds has attracted growing interest since nature has already provided some important anti-cancer drugs. This review compiles, for the first time, research regarding the anticancer activity of halophytes from different families, including, whenever possible, the bioactive molecules involved in such therapeutical properties along with possible mechanisms of action. The introduction section provides some pertinent information regarding cancer and a summary of the most important characteristics of halophytes. The next section gives information regarding the in vitro and in vivo cytotoxic properties of several halophyte species, grouped by families, including contents in bioactive metabolites and proposed modes of action, if possible. Lastly, the conclusion presents the most relevant metabolites and/or promising species and extracts that could be further explored in anticancer drug research.pt_PT
dc.description.sponsorshipLA/P/0101/2020
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPharmaceutics 14 (11): 2406 (2022)pt_PT
dc.identifier.doi10.3390/pharmaceutics14112406pt_PT
dc.identifier.eissn1999-4923
dc.identifier.urihttp://hdl.handle.net/10400.1/18503
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCancerpt_PT
dc.subjectNatural productspt_PT
dc.subjectCytotoxicpt_PT
dc.subjectSalt-tolerant plantspt_PT
dc.subjectAntitumoral drugspt_PT
dc.titleHalophyte plants as potential sources of Anticancer agents: a comprehensive reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00425%2F2017%2FCP1391%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PRIMA%2F0002%2F2019/PT
oaire.citation.issue11pt_PT
oaire.citation.startPage2406pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2017
oaire.fundingStream3599-PPCDT
person.familyNameCustódio
person.familyNameGuerreiro Pereira
person.familyNameCastelo-Branco
person.givenNameLuísa
person.givenNameCatarina Alexandra
person.givenNamePedro
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-idE015-7F8F-5CA1
person.identifier.orcid0000-0003-4338-7703
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0002-3453-3978
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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