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Revisiting the evolution of family B1 GPCRs and ligands: insights from mollusca

2024-05Journal article Open access
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dc.contributor.authorCardoso, João
dc.contributor.authorMc Shane, Jennifer
dc.contributor.authorLi, Zhi
dc.contributor.authorPeng, Maoxiao
dc.contributor.authorPower, Deborah Mary
dc.date.accessioned2024-09-09T10:33:31Z
dc.date.available2024-09-09T10:33:31Z
dc.date.issued2024-05
dc.description.abstractFamily B1 G protein-coupled receptors (GPCRs) are one of the most well studied neuropeptide receptor families since they play a central role in many biological processes including endocrine, gastrointestinal, cardiovascular and reproduction in animals. The genes for these receptors emerged from a common ancestral gene in bilaterian genomes and evolved via gene/genome duplications and deletions in vertebrate and invertebrate genomes. Their existence and function have mostly been characterized in vertebrates and few studies exist in invertebrate species. Recently, an increased interest in molluscs, means a series of genomes have become available, and since they are less modified than insect and nematode genomes, they are ideal to explore the origin and evolution of neuropeptide gene families. This review provides an overview of Family B1 GPCRs and their peptide ligands and incorporates new data obtained from Mollusca genomes and taking a comparative approach challenges existing models on their origin and evolution.eng
dc.description.sponsorshipFCT/AKDN/541666287/2019; EMBRC.PT ALG-01-0145-FEDER- 022121
dc.identifier.doi10.1016/j.mce.2024.112192
dc.identifier.issn0303-7207
dc.identifier.urihttp://hdl.handle.net/10400.1/25862
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relation.ispartofMolecular and Cellular Endocrinology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEvolution
dc.subjectGPCRs
dc.subjectLigands
dc.subjectMolluscs
dc.subjectOrigin
dc.subjectReceptor-ligand pairs
dc.titleRevisiting the evolution of family B1 GPCRs and ligands: insights from molluscaeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.citation.startPage112192
oaire.citation.titleMolecular and Cellular Endocrinology
oaire.citation.volume586
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCardoso
person.familyNameMc Shane
person.familyNameLi
person.familyNamePeng
person.familyNamePower
person.givenNameJoão
person.givenNameJennifer
person.givenNameZhi
person.givenNameMaoxiao
person.givenNameDeborah Mary
person.identifierR-000-75E
person.identifier.ciencia-id5C1C-8247-D614
person.identifier.ciencia-id361E-ECE9-BC00
person.identifier.ciencia-id0A1D-96B9-27EB
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-7353-1799
person.identifier.orcid0000-0001-8515-476X
person.identifier.orcid0000-0002-4255-4170
person.identifier.orcid0000-0002-4855-1202
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridC-5552-2008
person.identifier.scopus-author-id9639597300
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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