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Multidisciplinary approach and treatment of acral and mucosal melanoma

2024-02-26Journal article Open access
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dc.contributor.authorFortuna, Ana
dc.contributor.authorAmaral, Teresa
dc.date.accessioned2024-11-26T11:50:03Z
dc.date.available2024-11-26T11:50:03Z
dc.date.issued2024-02-26
dc.description.abstractAcral and mucosal melanoma are uncommon variants of melanoma. Acral melanoma has an age-adjusted incidence of approximately 1.8 cases per million individuals per year, accounting for about 2% to 3% of all melanoma cases. On the other hand, mucosal melanoma, with an incidence of 2.2 cases per million per year, makes up around 1.3% of all melanoma cases. These melanomas, in addition to being biologically and clinically distinct from cutaneous melanoma, share certain clinical and pathologic characteristics. These include a more aggressive nature and a less favorable prognosis. Furthermore, they exhibit a different mutational pattern, with KIT mutations being more prevalent in acral and mucosal melanomas. This divergence in mutational patterns may partially account for the relatively poorer prognosis, particularly to immune checkpoint inhibitors. This review explores various aspects of acral and mucosal melanoma, including their clinical presentation, pathologic features, mutational profiles, current therapeutic approaches, outcomes associated with systemic therapy, and potential strategies to address resistance to existing treatments.eng
dc.identifier.doi10.3389/fonc.2024.1340408
dc.identifier.issn2234-943X
dc.identifier.urihttp://hdl.handle.net/10400.1/26341
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relation.hasversionhttps://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1340408/full
dc.relation.ispartofFrontiers in Oncology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAcral Melanoma
dc.subjectMucosal Melanoma
dc.subjectKIT Mutations
dc.subjectGNAQ Mutation
dc.subjectGNA11 Mutation
dc.subjectImmunotherapy
dc.subjectTargeted Therapy
dc.subjectLocal Therapy
dc.titleMultidisciplinary approach and treatment of acral and mucosal melanomaeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage19
oaire.citation.startPage1
oaire.citation.titleFrontiers in Oncology
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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