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Fatigue and mental illness symptoms in long COVID: protocol for a prospective cohort multicenter observational study

2024Journal article Open access
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dc.contributor.authorPires, Ligia
dc.contributor.authorReis, Cláudia
dc.contributor.authorMesquita Facão, Ana Rita
dc.contributor.authorMoniri, Armin
dc.contributor.authorMarreiros, Ana
dc.contributor.authorDrummond, Marta
dc.contributor.authorBerger-Estilita, Joana
dc.date.accessioned2024-03-14T10:02:31Z
dc.date.available2024-03-14T10:02:31Z
dc.date.issued2024
dc.description.abstractBackground: The aftermath of the COVID-19 pandemic continues to affect millions worldwide, resulting in persisting postvirus complaints and impacting peoples' quality of life. Long COVID, characterized by lingering symptoms like fatigue and mental illness, can extend beyond a few months, necessitating further research to understand its implications. Objective: This study aims to quantify the degree of physical and psychological fatigue in patients following COVID-19 infection and examine its correlation with mental health disorders. Methods: Using a consecutive nonrandom sampling technique, we will conduct a prospective cohort multicenter observational study in 5 Portuguese hospitals. Symptomatic adult patients with previous COVID-19 attending follow-up consultations will be enrolled. We will include patients who had mild, moderate, and severe acute disease. We will assess clinical outcomes related to COVID-19, including the type of respiratory support such as high-flow nasal cannula, noninvasive ventilation, and invasive mechanical ventilation. The exclusion criteria will include previous severe psychiatric disorders confirmed by a psychiatrist; refusal or inability to respond to the questionnaire; concomitant neurological disorder; persistent fatigue symptoms during the 6 months before infection; and the need for invasive mechanical ventilation during COVID-19 infection due to a high prevalence of postintensive care syndrome. Our primary outcome is the prevalence of fatigue in patients with post-COVID-19 depression and/or anxiety, as measured by the Chalder Fatigue Scale (CFQ-11) and the Hospital Anxiety and Depression Scale (HADS). The secondary outcomes will include an assessment of health-related quality of life via the EQ-5D questionnaire and an exploration of the prevalence of symptoms of posttraumatic stress disorder (PTSD) using the 14-item Posttraumatic Stress Scale (PTSS-14). We will also examine the association between mental health symptoms and the severity of acute COVID-19. The post-COVID-19 data will be collected at least 6 months after the positive test and no longer than 9 months during the clinical appointment. Results: We expect our multicenter study on patients post COVID-19 to reveal a significant link between mental illness symptoms and both physical and psychological fatigue. Patients with heightened depression and anxiety may report increased levels of fatigue. Additionally, we expect to find persistent PTSD symptoms in a subset of participants, indicating the enduring psychological impact of the virus. Conclusions: This study may underscore the need for integrated care addressing physical and mental health in patients post COVID-19. The observed connections emphasize the importance of considering mental well-being for long-term health outcomes. Despite study limitations, our findings contribute valuable insights for future treatment strategies and highlight the necessity for comprehensive mental health support in post-COVID-19 care. This research provides valuable insights into the mental health implications of COVID-19 and its impact on post-COVID-19 fatigue and the overall well-being of affected individuals.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2196/51820pt_PT
dc.identifier.issn1929-0748
dc.identifier.urihttp://hdl.handle.net/10400.1/20508
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJMIR Publicationspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSARS-CoV-2;pt_PT
dc.subjectCoronaviruspt_PT
dc.subjectCOVIDpt_PT
dc.subjectLong COVIDpt_PT
dc.subjectFatiguept_PT
dc.subjectTiredpt_PT
dc.subjectTirednesspt_PT
dc.subjectAnxietypt_PT
dc.subjectDepressionpt_PT
dc.subjectPTSDpt_PT
dc.subjectStresspt_PT
dc.subjectQuality of lifept_PT
dc.subjectMental healthpt_PT
dc.subjectPost-COVID-conditionpt_PT
dc.subjectNeuropsychologicalpt_PT
dc.subjectNeuropsychologypt_PT
dc.subjectPsychologicalpt_PT
dc.subjectLong COVID-19pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectMyalgiapt_PT
dc.subjectCorrelationpt_PT
dc.subjectImpairmentpt_PT
dc.titleFatigue and mental illness symptoms in long COVID: protocol for a prospective cohort multicenter observational studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagee51820pt_PT
oaire.citation.titleJMIR Research Protocolspt_PT
oaire.citation.volume13pt_PT
person.familyNameMoniri
person.familyNameMarreiros
person.givenNameArmin
person.givenNameAna
person.identifier.ciencia-id9A12-9450-7051
person.identifier.orcid0000-0002-6054-5980
person.identifier.orcid0000-0001-9410-4772
person.identifier.scopus-author-id57194785077
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0fab8330-d1aa-4210-b91c-5547de263033
relation.isAuthorOfPublicationc0a8e5da-26ae-42a8-ab04-fa4df4356375
relation.isAuthorOfPublication.latestForDiscovery0fab8330-d1aa-4210-b91c-5547de263033

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