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Stressor controllability modulates the stress response in fish

2021-08-04Journal article Open Access
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dc.contributor.authorCerqueira, Marco
dc.contributor.authorMillot, Sandie
dc.contributor.authorSilva, Tomé
dc.contributor.authorFélix, Ana S.
dc.contributor.authorCastanheira, Maria Filipa
dc.contributor.authorRey, Sonia
dc.contributor.authorMacKenzie, Simon
dc.contributor.authorOliveira, Gonçalo A.
dc.contributor.authorOliveira, Catarina
dc.contributor.authorOliveira, Rui F.
dc.date.accessioned2021-09-01T09:49:32Z
dc.date.available2021-09-01T09:49:32Z
dc.date.issued2021-08-04
dc.date.updated2021-09-01T03:25:00Z
dc.description.abstractBackground In humans the stress response is known to be modulated to a great extent by psychological factors, particularly by the predictability and the perceived control that the subject has of the stressor. This psychological dimension of the stress response has also been demonstrated in animals phylogenetically closer to humans (i.e. mammals). However, its occurrence in fish, which represent a divergent vertebrate evolutionary lineage from that of mammals, has not been established yet, and, if present, would indicate a deep evolutionary origin of these mechanisms across vertebrates. Moreover, the fact that psychological modulation of stress is implemented in mammals by a brain cortical top-down inhibitory control over subcortical stress-responsive structures, and the absence of a brain cortex in fish, has been used as an argument against the possibility of psychological stress in fish, with implications for the assessment of fish sentience and welfare. Here, we have investigated the occurrence of psychological stress in fish by assessing how stressor controllability modulates the stress response in European seabass (Dicentrarchus labrax). Results Fish were exposed to either a controllable or an uncontrollable stressor (i.e. possibility or impossibility to escape a signaled stressor). The effect of loss of control (possibility to escape followed by impossibility to escape) was also assessed. Both behavioral and circulating cortisol data indicates that the perception of control reduces the response to the stressor, when compared to the uncontrollable situation. Losing control had the most detrimental effect. The brain activity of the teleost homologues to the sensory cortex (Dld) and hippocampus (Dlv) parallels the uncontrolled and loss of control stressors, respectively, whereas the activity of the lateral septum (Vv) homologue responds in different ways depending on the gene marker of brain activity used. Conclusions These results suggest the psychological modulation of the stress response to be evolutionary conserved across vertebrates, despite being implemented by different brain circuits in mammals (pre-frontal cortex) and fish (Dld-Dlv).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Neuroscience. 2021 Aug 04;22(1):48pt_PT
dc.identifier.doi10.1186/s12868-021-00653-0pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.1/16915
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Centralpt_PT
dc.relationA new integrative framework for the study of fish welfare based on the concepts of allostasis, appraisal and coping styles
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectStresspt_PT
dc.subjectControllabilitypt_PT
dc.subjectCortisolpt_PT
dc.subjectImmediate early genespt_PT
dc.subjectDorsolateral palliumpt_PT
dc.subjectFish welfarept_PT
dc.titleStressor controllability modulates the stress response in fishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA new integrative framework for the study of fish welfare based on the concepts of allostasis, appraisal and coping styles
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/265957/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F80029%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F72952%2F2010/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage48pt_PT
oaire.citation.titleBMC Neurosciencept_PT
oaire.citation.volume22pt_PT
oaire.fundingStreamFP7
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameCerqueira
person.familyNameCastanheira
person.familyNameOliveira
person.givenNameMarco
person.givenNameMaria Filipa
person.givenNameCatarina
person.identifier.ciencia-id4F1E-16FC-00D8
person.identifier.ciencia-id0816-30C5-51AC
person.identifier.orcid0000-0001-7237-5053
person.identifier.orcid0000-0001-5901-4077
person.identifier.orcid0000-0002-6679-761X
person.identifier.scopus-author-id35433190500
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication468ec69f-f93b-4db1-970b-1009035a2157
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relation.isAuthorOfPublication3ac5841f-3b4e-4ad1-94f7-a5436fb8cd59
relation.isAuthorOfPublication.latestForDiscovery478e6c75-7e85-4b20-95f6-486ff4b3ac32
relation.isProjectOfPublication19a75e7e-7ad9-4828-bc77-8fd65e03afcb
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