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Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer

2020-06Journal article Open access
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dc.contributor.authorVarela, Tatiana
dc.contributor.authorLaizé, Vincent
dc.contributor.authorConceição, Natércia
dc.contributor.authorCaldeira, Paulo
dc.contributor.authorMarreiros, Ana
dc.contributor.authorGuerreiro, Horacio
dc.contributor.authorCancela, M. Leonor
dc.date.accessioned2021-06-24T11:35:30Z
dc.date.available2021-06-24T11:35:30Z
dc.date.issued2020-06
dc.description.abstractAim: To provide novel data on the expression of DUSP4 transcripts in colorectal cancer (CRC) tissues and to explore their potential as biomarkers. Materials & methods:DUSP4 transcripts expression was determined by quantitative real-time PCR in tissues from 28 CRC patients. Their association with clinicopathological factors and survival analysis was performed. Data from 380 CRC patients available at The Cancer Genome Atlas project were also analyzed. Results: All transcripts were overexpressed in CRC tissues. Variant X1 was the most upregulated and associated with KRAS mutations and poorly differentiated tumor. Overexpression of DUSP4 transcripts could distinguish all tumor stages from normal tissues. Similar results were found in The Cancer Genome Atlas cohort. Conclusion:DUSP4 transcripts have the potential to serve as diagnostic biomarkers for CRC, particularly variant X1.
dc.description.sponsorshipPortuguese Foundation for Science and Technology (FCT)Portuguese Foundation for Science and Technology [UIDB/04326/2020]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.2217/bmm-2019-0369
dc.identifier.issn1752-0363
dc.identifier.urihttp://hdl.handle.net/10400.1/16460
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFuture Science Group
dc.relationAlgarve Centre for Marine Sciences
dc.subjectBiomarker
dc.subjectColorectal cancer
dc.subjectDUSP4
dc.subjectGene expression
dc.subjectTranscript variants
dc.subject.otherResearch & Experimental Medicine
dc.titleExpression of DUSP4 transcript variants as a potential biomarker for colorectal cancer
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.citation.endPage650
oaire.citation.issue8
oaire.citation.startPage639
oaire.citation.titleBiomarkers In Medicine
oaire.citation.volume14
oaire.fundingStream6817 - DCRRNI ID
person.familyNameVarela
person.familyNameLaizé
person.familyNameConceição
person.familyNameCaldeira
person.familyNameMarreiros
person.familyNameGuerreiro
person.familyNameCancela
person.givenNameTatiana da Conceição Domingos
person.givenNameVincent
person.givenNameNatércia
person.givenNamePaulo
person.givenNameAna
person.givenNameHoracio
person.givenNameM. Leonor
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person.identifier.orcid0000-0001-9410-4772
person.identifier.orcid0000-0002-1387-5813
person.identifier.orcid0000-0003-3114-6662
person.identifier.ridB-4463-2008
person.identifier.scopus-author-id6602982778
person.identifier.scopus-author-id57194785077
person.identifier.scopus-author-id57188667152
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a CiĂȘncia e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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