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Bioprospecting marine fungi from the plastisphere: osteogenic and antiviral activities of fungal extracts

2025-03-07Journal article Open access
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dc.contributor.authorFurno, Matteo Florio
dc.contributor.authorLaizé, Vincent
dc.contributor.authorArduino, Irene
dc.contributor.authorPham, Giang Nam
dc.contributor.authorSpina, Federica
dc.contributor.authorMehiri, Mohamed
dc.contributor.authorLembo, David
dc.contributor.authorGavaia, Paulo
dc.contributor.authorVarese, Giovanna Cristina
dc.date.accessioned2025-04-22T09:10:40Z
dc.date.available2025-04-22T09:10:40Z
dc.date.issued2025-03-07
dc.description.abstractMarine microplastics (MPs) represent a novel ecological niche, populated by fungi with high potential for pharmaceutical discovery. This study explores the bioactivity of fungal strains isolated from MPs in Mediterranean sediments, focusing on their osteogenic and antiviral activities. Crude extracts prepared via solid-state and submerged-state fermentation were tested for their effects on extracellular matrix mineralization in vitro and bone growth in zebrafish larvae, and for their activity against the respiratory syncytial virus (RSV) and herpes simplex virus type 2 (HSV-2). Several extracts exhibited significant mineralogenic and osteogenic activities, with Aspergillus jensenii MUT6581 and Cladosporium halotolerans MUT6558 being the most performing ones. Antiviral assays identified extracts from A. jensenii MUT6581 and Bjerkandera adusta MUT6589 as effective against RSV and HSV-2 at different extents, with no cytotoxic effect. Although chemical profiling of A. jensenii MUT6581 extract led to the isolation of decumbenones A and B, they did not reproduce the observed bioactivities, suggesting the involvement of other active compounds or synergistic effects. These results highlight the plastisphere as a valuable resource for novel bioactive compounds and suggest the need for further fractionation and characterization to identify the molecules responsible for these promising activities.eng
dc.description.sponsorshipEMBRC.PT ALG-01-0145-FEDER-022121, IR0000005, PE00000007
dc.identifier.doi10.3390/md23030115
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.1/27062
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relation.ispartofMarine Drugs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSecondary metabolites
dc.subjectPlastisphere
dc.subjectAspergillus jensenii
dc.subjectSSF
dc.subjectSmF
dc.subjectMicroplastics
dc.titleBioprospecting marine fungi from the plastisphere: osteogenic and antiviral activities of fungal extractseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.citation.issue3
oaire.citation.startPage115
oaire.citation.titleMarine Drugs
oaire.citation.volume23
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLaizé
person.familyNameGavaia
person.givenNameVincent
person.givenNamePaulo
person.identifier.ciencia-idB619-FC16-D007
person.identifier.orcid0000-0001-9565-9198
person.identifier.orcid0000-0002-9582-1957
person.identifier.ridB-4463-2008
person.identifier.ridA-6470-2011
person.identifier.scopus-author-id6602982778
person.identifier.scopus-author-id6507104377
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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relation.isAuthorOfPublication9dca2139-21a4-4d59-aaf7-531f1033a58e
relation.isAuthorOfPublication.latestForDiscoveryb51cd3d5-7ee4-47d8-9bc4-b3e297aa222f
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relation.isProjectOfPublication15f91d45-e070-47d8-b6b8-efd4de31d9a8
relation.isProjectOfPublication.latestForDiscoveryfafa76a6-2cd2-4a6d-a3c9-772f34d3b91f

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