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Matrix Gla protein repression by miR-155 promotes oncogenic signals in breast cancer MCF-7 cells

2016-04Journal article Restricted access
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dc.contributor.authorTiago, Daniel
dc.contributor.authorConceição, Natércia
dc.contributor.authorCaiado, Helena
dc.contributor.authorLaizé, Vincent
dc.contributor.authorCancela, Leonor
dc.date.accessioned2017-04-07T15:56:49Z
dc.date.available2017-04-07T15:56:49Z
dc.date.issued2016-04
dc.description.abstractMGP is a protein that was initially associated with the inhibition of calcification in skeleton, soft tissues, and arteries, but more recently also implicated in cancer. In breast cancer, higher levels of MGP mRNA were associated with poor prognosis, but since this deregulation was never demonstrated at the protein level, we postulated the involvement of a post-transcriptional regulatory mechanism. In this work we show that MGP is significantly repressed by miR-155 in breast cancer MCF-7 cells, and concomitantly there is a stimulation of cell proliferation and cell invasiveness. This study brings new insights into the putative involvement of MGP and oncomiR-155 in breast cancer, and may contribute to develop new therapeutic strategies.
dc.identifier.doi10.1002/1873-3468.12155
dc.identifier.issn0014-5793
dc.identifier.otherAUT: LCA00739;
dc.identifier.urihttp://hdl.handle.net/10400.1/9536
dc.language.isoeng
dc.peerreviewedyes
dc.relationStrategic Project - LA 15 - 2011-2012
dc.relationFunctional analysis of OPTN and SQSTM1 mutations in Paget´s disease of bone
dc.relation.isbasedonWOS:000375008700020
dc.titleMatrix Gla protein repression by miR-155 promotes oncogenic signals in breast cancer MCF-7 cells
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 15 - 2011-2012
oaire.awardTitleFunctional analysis of OPTN and SQSTM1 mutations in Paget´s disease of bone
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FMAR%2FLA0015%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F111898%2F2015/PT
oaire.citation.endPage1241
oaire.citation.issue8
oaire.citation.startPage1234
oaire.citation.titleFEBS Letters
oaire.citation.volume590
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStream5876
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameTiago
person.familyNameCaiado
person.familyNameLaizé
person.familyNameCancela
person.givenNameDaniel
person.givenNameHelena
person.givenNameVincent
person.givenNameM. Leonor
person.identifier.ciencia-id7D19-F0E4-4166
person.identifier.orcid0000-0001-8418-6292
person.identifier.orcid0000-0002-2754-8266
person.identifier.orcid0000-0001-9565-9198
person.identifier.orcid0000-0003-3114-6662
person.identifier.ridB-4463-2008
person.identifier.scopus-author-id14422711000
person.identifier.scopus-author-id6602982778
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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